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dc.contributor.authorAtay, Emre
dc.contributor.authorErtekin, Ayşe
dc.contributor.authorBozkurt, Erhan
dc.contributor.authorAslan, Esra
dc.descriptionAtay, Emre/0000-0002-2378-1183; Bozkurt, Erhan/0000-0002-1853-7098en_US
dc.descriptionPubMed: 32864885en_US
dc.description.abstractObjectives Bisphenol A (BPA) is one of the most heavily produced chemicals in the world. BPA is involved in the production of many substances such as cosmetics, various foodstuffs, toys, personal care products, detergents and plastic bottles all that are frequently used in daily life. Depending on BPA exposure, sexual maturation and reproductive function, and bone and brain development are adversely affected. The aim of this study is to investigate the possible effects of BPA on the development of the nervous system and neural tube in 48-hr chicken embryos. Methods Thirty specific pathogen-free (SPF) fertilized eggs were used in the study. SPF eggs were placed in the incubator and divided into three groups at 28 hr of incubation; control, BPA 1 and BPA 2 (10 eggs in each group). At this stage of incubation, two different doses of BPA were injected sub-blastodermically with the Hamilton microinjector. At the end of 48 hr of incubation, all eggs were opened and embryos were dissected and separated from the embryonic membrane. All embryos were evaluated morphologically and histopathologically. Results As the BPA dose increased, delays in the development of the nervous system and midline closure increased in the early period of chicken embryos. Depending on the dose, it was found that the embryo's crown-rump length and somite number decreased (p < .05). Conclusion It was determined that BPA application on early chicken embryos adversely affected neural tube development. It was also found to delay midline closure.en_US
dc.subjectBisphenol Aen_US
dc.subjectchicken embryoen_US
dc.subjectnervous systemen_US
dc.subjectneural tubeen_US
dc.titleImpact of Bisphenol A on neural tube development in 48-hr chicken embryosen_US
dc.departmentAFSÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalıen_US
dc.contributor.institutionauthorAtay, Emre
dc.contributor.institutionauthorErtekin, Ayşe
dc.contributor.institutionauthorBozkurt, Erhan
dc.contributor.institutionauthorAslan, Esra
dc.relation.journalBirth Defects Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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