dc.contributor.author | Kutlay, Özden | |
dc.contributor.author | Keskin Aktan, Arzu | |
dc.contributor.author | Aslan, Esra | |
dc.date.accessioned | 2022-04-29T13:08:00Z | |
dc.date.available | 2022-04-29T13:08:00Z | |
dc.date.issued | 19.10.2021 | en_US |
dc.identifier.citation | Kutlay, Ö., Aktan, A. K., & Aslan, E. (2022). The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide. Canadian journal of physiology and pharmacology, 100(4), 314-323. | en_US |
dc.identifier.issn | 0008-4212 | |
dc.identifier.issn | 1205-7541 | |
dc.identifier.uri | https://doi.org/10.1139/cjpp-2021-0337 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12933/884 | |
dc.description.abstract | Cyclophosphamide is a chemotherapeutic drug that is widely used in the clinic and can cause multi-organ toxicity. Apelin-13 is an endogenous adipocytokine with antioxidant properties. Therefore, this study investigated the possibility of apelin-13 being a potential therapeutic agent on cardiac toxicity and nephrotoxicity caused by cyclophosphamide. In this study, a total of four groups were formed with eight rats in each group. Group I: the control group was administered only saline (i.p.). Group II: cyclophosphamide, a single dose of 200 mg/kg (i.p.) on day 7. Group III: apelin-13 (15 μg/kg), for 7 days (i.p.). Group IV: administered apelin-13 (15 μg/kg) (i.p.) for 7 days and a single dose of cyclophosphamide (200 mg/kg) (i.p.) on day 7, the rats were sacrificed on day 8. Lactate dehydrogenase, cardiac troponin I (cTnI), creatine kinase MB (CK-MB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), malondialdehyde, creatinine, and blood urea nitrogen were found to be high in the cyclophosphamide group; however, these values were reduced with apelin-13 administration. Antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase, and reduced glutathione (GSH) decreased in the cyclophosphamide group, and apelin-13 increased these enzyme activities. In addition, histopathological examinations also supported the results obtained. The findings of this study showed that apelin-13 has a protective effect against cardiorenal toxicity caused by cyclophosphamide. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Canadian Science Publishing | en_US |
dc.relation.isversionof | 10.1139/cjpp-2021-0337 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Apelin-13 | en_US |
dc.subject | Apeline-13 | en_US |
dc.subject | Cardiotoxicity | en_US |
dc.subject | Cardiotoxicité | en_US |
dc.subject | Cyclophosphamide toxicity | en_US |
dc.subject | Nephrotoxicity | en_US |
dc.subject | Néphrotoxicité | en_US |
dc.subject | Toxicité de la cyclophosphamide | en_US |
dc.title | The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide | en_US |
dc.type | article | en_US |
dc.authorid | 0000-0001-5509-6650 | en_US |
dc.authorid | 0000-0002-2878-0841 | en_US |
dc.authorid | 0000-0002-3191-4978 | en_US |
dc.department | AFSÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.contributor.institutionauthor | Kutlay, Özden | |
dc.contributor.institutionauthor | Keskin Aktan, Arzu | |
dc.contributor.institutionauthor | Aslan, Esra | |
dc.identifier.volume | 100 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 314 | en_US |
dc.identifier.endpage | 323 | en_US |
dc.relation.journal | Canadian Journal of Physiology and Pharmacology | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |