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dc.contributor.authorBeysel, Selvihan
dc.contributor.authorÇalışkan, Mustafa
dc.contributor.authorKızılgül, Muhammed
dc.contributor.authorApaydın, Mahmut
dc.contributor.authorKan, Seyfullah
dc.contributor.authorÖzbek, Mustafa
dc.contributor.authorÇakal, Erman
dc.descriptionPubMed: 31068134en_US
dc.description.abstractBackgroundParathyroidectomy has ameliorated cardiovascular risk factors in patients with hypercalcemic primary hyperparathyroidism (PHPT), but the effect of parathyroidectomy on normocalcemic PHPT is not exactly known. This case-controlled study aimed to investigate the effect of parathyroidectomy on cardiovascular risk factors in patients with normocalcemic and hypercalcemic PHPT.MethodsSubjects with normocalcemic PHPT (n=35), age- and sex-matched hypercalcemic PHPT (n=60) and age- and sex-matched control (n=60) were included. Cardiometabolic disorders were investigated with traditional cardiometabolic risk factors and the Framingham cardiovascular risk score (CRS) before and 6months after parathyroidectomy.ResultsDiabetes, dyslipidemia, hypertension, obesity, insulin resistance, osteoporosis, having fractures were similarly increased in the hypercalcemic and normocalcemic PHPT groups (p>0.05) compared with the controls (p<0.05). Blood pressures, glucose metabolism (glucose, insulin, HOMA-IR) and lipid profiles were similarly increased in the PHPT groups (p>0.05) compared with the controls (p<0.05). After parathyroidectomy, blood pressures, serum total cholesterol, and HOMA-IR were decreased in both PHPT groups (p<0.05). CRS was lower in the controls (5.743.24, p<0.05). After parathyroidectomy, CRS was decreased in the normocalcemic (11.98 +/- 10.11 vs. 7.37 +/- 4.48) and hypercalcemic (14.62 +/- 11.06 vs. 8.05 +/- 7.72) PHPT groups. Increased blood pressures were independent predictors of serum iPTH.Conclusion p id=Par4 The normocalcemic and hypercalcemic PHPT groups had similarly increased cardiovascular risk factors, even independently of serum calcium. Parathyroidectomy ameliorated the increased cardiovascular risk factors in both normocalcemic and hypercalcemic PHPT.en_US
dc.subjectNormocalcemic primary hyperparathyroidismen_US
dc.subjectHypercalcemic primary hyperparathyroidismen_US
dc.subjectCardiovascular risken_US
dc.titleParathyroidectomy improves cardiovascular risk factors in normocalcemic and hypercalcemic primary hyperparathyroidismen_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorBeysel, Selvihan
dc.relation.journalBmc Cardiovascular Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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