Macro-CK in carbon monoxide poisoning: A guide for in-hospital mortality?

Abstract

Carbon monoxide (CO) poisoning is common in developing countries and can be mortal. CO poisoning can present with various signs and symptoms. In addition, it has been observed that some people have increased cardiovascular diseases and are associated with high mortality. In this study, the usability of Macro creatine-kinase (Macro-CK) for in-hospital mortality detection in CO poisoning was investigated. This study is a retrospective and single-center study. Data of patients diagnosed with CO poisoning were accessed from the hospital automation system. Macro-CK was accepted for patients with CK-MB higher than total CK. The patients were divided into two groups according to the Macro-CK determination. Macro-CK detected patients were arranged as group-1, and the others as group-2. In-hospital mortality rates were determined in the groups and compared between groups and analyzed. 1100 patients were eligible for the study. Of these patients, Macro-CK was detected in 33 patients (0.03%). The mean age of the patients was 37.6 ± 16.9 and 43.2% were male. In-hospital mortality was 20 (60.6%) in group 1, and 50 (4.7%) in group 2 and was statistically significant (p<0.001). As a result of the regression analysis, it was determined that Macro-CK was statistically significant with in-hospital mortality (p=0.001). This result shows us that as the Macro-CK increases, the mortality also increases. Our study is the first study in the literature investigating the relationship between Macro-CK and mortality in CO poisoning. It is a study in which Macro-CK is determined as an independent predictor of in-hospital mortality.