Relationship between Inflammatory Markers and General Characteristics in Endometrial Cancer Cancer; Prognostic Value of the HALP Index

Abstract

Objectives: A promising cancer-predictive biomarker is the hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a comprehensive indicator of nutrition and systemic inflammation. There needs to be more data on the HALP index and EC, and to our knowledge, there is no investigation into how this indicator would have predicted EC in the Turkish population. Methods: In this retrospective study, EC individuals with uterine cancer underwent surgery between January 2010 and December 2020, all data were collected from the hospital records. Results: This retrospective study revealed 163 non-metastatic endometrial cancer (median age was 61, ranging from 41 to 84 years). The mean HALP index was 43 (min 10-max 115). HALP index levels were significantly decreased from FIGO stage I to stage III (mean values were 50, 40, and 27). Lymph node metastasis was detected in 11 patients with significantly lower HALP index compared to lymph node-free patients (30 vs 44, p=0.018). Conclusion: This is the first study in our population we found the HALP index is a good prognostic marker to predict pathologic features for early-stage endometrial cancer.