Comparison of Daily Home Blood Pressure Variability in Type 2 Diabetes Mellitus Patients With and Without Diabetic Nephropathy

Abstract

Objectives: In this study, we aimed to compare daily home blood pressure (BP) variability in Type 2 diabetes mellitus patients with and without diabetic kidney disease (DKD). Methods: We reviewed all Type 2 diabetic patients’ files admitted to the nephrology outpatient clinic between Janu- ary 2021 and January 2022. Patients who applied to our outpatient clinic with 10-day BP measurements at home were included in the study. Patients with ?30 mg/g albumin excretion were defined as patients with DKD. Patients with albumin excretion <30 mg/g were defined as patients without DKD. Systolic and diastolic BP variability was evaluated with the average real variability (ARV). Results: The study was conducted with a total of 243 Type 2 diabetes mellitus patients. The mean age of the patients was 55.4±14.9 years. Systolic ARV (SysARV) was found statistically significantly higher in patients with DKD (p=0.009). SysARV was also found to be statistically significantly higher in patients with severe albuminuria than in patients with moderate albuminuria (p<0.001). Diastolic ARVs was found to be similar between patients with and without DKD and in albuminuria groups in patients with DKD (p=0.289 and p=0.171, respectively). Conclusion: The present study shows that systolic BP variability is higher in patients with DKD. Type 2 diabetic patients with higher SysARV can be followed more closely in terms of DKD.