Comparative Study of The Anti-Inflammatory Pathway Enzyme Activities of Selected Plant Extracts from Lamiaceae Family

Abstract

In this study, the effects of selected plants from the Lamiaceae family (Mentha piperita L., Salvia officinalis L., Lavandula officinalis Chaix., Scutellaria orientalis L. and Melissa officinalis L.) on the activities of lipoxygenase- 12/15 (LOX-12/15), cyclooxygenase-2 (COX-2) and acetylcholinesterase (AChE) enzymes, which have an essential place in the inflammation pathway, were determined. They have been studied as an alternative to inhibitor drugs that have many side effects. The metabolomic profiles of the extracts were defined by GC-MS and LC-qTOF-MS methods. The antioxidant parameters of the extracts were investigated by DPPH+ radical scavenging activity and TAC methods. The time-dependent scavenging capacity of extracts for DPPH+ radicals varies depending on the extracts, time, and concentration. The potential inhibitory effects of the extracts on 12-15-LOX, COX-2, and AChE enzymes were compared with metabolomics analysis. Our combined results suggest that the extracts have potential use as anti-inflammatory agents. © 2024 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.