Unilateral orbital eosinophilic cellulitis (Wells syndrome)

Abstract

Eosinophilic cellulitis, also known as Wells syndrome, is a rare inflammatory skin disorder of unknown etiology. The disease has no known racial or sexual predisposition. It usually affects adults, although it can also be observed in children. Typically, it begins as a solitary burning or pruritic erythematous, edematous, and urticarial plaque, which usually has an acute cellulitis-like appearance. Nodules, blisters, or bullae may develop later in the initial lesion. The disease follows a pattern of spontaneous relapse and remission. The extremities and trunk are the most commonly involved localizations, but only a few cases of solely orbital involvement have been reported. Herein, we present a case of unilateral orbital eosinophilic cellulitis that remained undiagnosed for a long period. ©© 2025 The Author.