From extract to chiral analyses of the natural products

Abstract

Chiral natural products play a prominent role in medicinal chemistry because of their distinct biological activity and complex structure. This chapter addresses the process of extracting and analyzing chiral chemicals, focusing on the important techniques and approaches used to isolate and characterize these crucial substances. The chapter starts with an exploration of the significance of natural products and chirality. It then proceeds to examine a range of extraction techniques, encompassing both traditional and modern methods, employed for the acquisition of chiral natural products. Next, it discusses advanced approaches for isolating substances, with a focus on chromatographic and crystallization techniques, as well as the importance of high-performance liquid chromatography (HPLC). The importance of chiral analysis in understanding the pharmacological characteristics of these substances is highlighted, accompanied by comprehensive elucidations of chromatographic, electrophoretic, and polarimetric techniques. The applicability of chiral analysis in real-world circumstances is demonstrated through specific instances. This chapter is a helpful resource for academics and experts in the field. Its purpose is to enhance the understanding and utilization of chiral natural products in medication development. © 2025 Elsevier Inc. All rights reserved.