Evaluation of biopsy performed childhood lymphadenopathies: Single center experience Evaluation of childhood lymphadenopathies

Abstract

Aim: The aim of the study was to evaluate patients who were followed up with lymphadenopathy and underwent biopsy in Afyon Health Sciences University Pediatric Hematology/Oncology Department and to assess the potential correlations between the presence of antibodies against EBV antigens in serum samples and the presence of EBER in lymph node tissues. Material and Methods: All cases diagnosed with lymphadenopathy and excisional biopsy performed in the Pediatric Hematology and Oncology Department, between January 2018 to January 2020 were retrospectively evaluated. Medical records (gender, age, medical history, sore throat, fever, cough, history of upper respiratory tract infection, animal contact and travel, duration of symptoms) of patients, as well as their treatment history were examined. Tissue EBER status, serological tests for EBV (EBV VCA IgG, VCA IgM, EBNA IgG, EBNA IgM, and EA IgG) data were recorded from files. Results: Our study included 22 patients comprising 10 females (%45.4) and 12 males (%54.5). At the time of the diagnosis, the median age was 8 (range, 2 to 17) years. Five (22.6%) of 22 biopsies were reported to be malignant. Reactive lymphoid hyperplasia was seen in 15 (68.1%) patients. Statistical analysis revealed a significant correlation between anti-VCA IgG serology and the EBER status (p=0.03). Discussion: In conclusion, lymphadenopathy is a common clinical condition in childhood and often develops due to reactive hyperplasia. It was determined that patients with serum EBVVCA IgG positive were also EBER positive in the tissue.