Candida Meningitis Accompanied by Upper Gastrointestinal Tract Candidiasis in an Immunocompromised Host

Abstract

Candida albicans, a normal component of the human skin, mouth, and respiratory tract flora, can cause opportunistic infections in immunocompromised individuals. It is a rare cause of meningitis. This study presents a case of Candida meningitis in a patient with psoriasis and ankylosing spondylitis treated with adalimumab. The patient presented with extensive oropharyngeal candidiasis lesions extending to the larynx and esophagus and was diagnosed with Candida meningitis. He was treated with intravenous fluconazole and liposomal amphotericin B combination therapy for 28 days. This case highlights the importance of early diagnosis and treatment of fungal meningitis in immunocompromised hosts.