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dc.contributor.authorEkici, Ömer
dc.contributor.authorAslan, Esra
dc.contributor.authorAladağ, Tuğçe
dc.contributor.authorGüzel, Hilal
dc.contributor.authorKorkmaz, Ömer Adil
dc.contributor.authorBostancı, Aykut
dc.contributor.authorSadi, Gökhan
dc.contributor.authorPektaş, Mehmet Bilgehan
dc.date.accessioned2021-05-05T22:14:03Z
dc.date.available2021-05-05T22:14:03Z
dc.date.issued2021
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.urihttps://doi.org/10.1111/jfbc.13732
dc.identifier.urihttps://hdl.handle.net/20.500.12933/232
dc.descriptionPektas, Mehmet Bilgehan/0000-0003-0055-7688; Ekici, Omer/0000-0002-7902-9601; Bostanci, Aykut/0000-0002-6855-0645en_US
dc.descriptionWOS:000640715000001en_US
dc.descriptionPubMed: 33864286en_US
dc.description.abstractThe aim of the study was to evaluate whether high-fructose corn syrup (HFCS) intake (20% beverages) impacts antioxidative structures and inflammation in the gingival tissue and masseter muscle of rats. Kefir was tested for its potential utility on changes induced by HFCS. Animals were randomly divided into four groups as control, kefir, HFCS, and HFCS plus kefir. HFCS was given as 20% solutions in drinking water while kefir supplementations were given by gastric gavage for 8 weeks. It has been clearly determined that the HFCS diet increased expressions of interleukin (IL)-6, IL-1 beta, and tumor necrosis factor-alpha proinflammatory structures via lymphocyte infiltration by suppressing antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase in both tissues. Kefir improved these undesirable changes in rats fed with HFCS. The results of this current study, the first investigation to examine the effects of kefir on masseter muscle and gingival tissue, may provide new access to the restorative effects of kefir consumption on oral health disorders caused by high fructose in the diet. Practical applications In this study, at an early age, the effects of kefir on improving inflammation via antioxidation in the masseter muscle and gingival tissue were investigated for the first time. We showed that kefir feeding ameliorates lymphocyte infiltration on the high-fructose corn syrup (HFCS)-induced masseter muscle and gingival tissue inflammation in rats. The mRNA expressions of inflammatory parameters measured in the study were supported by protein measurements via ELISA or immunohistochemistry. In the present study, kefir may play an important role in the antioxidation and inflammation process on the masseter muscle and gingival tissue against HFCS.en_US
dc.description.sponsorshipAfyonkarahisar Health Sciences University Research Foundation [19.Kariyer.016]en_US
dc.description.sponsorshipAfyonkarahisar Health Sciences University Research Foundation, Grant/Award Number: 19.Kariyer.016en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidantsen_US
dc.subjectgingivaen_US
dc.subjectHFCSen_US
dc.subjectinflammationen_US
dc.subjectkefiren_US
dc.subjectmasseter muscleen_US
dc.titleMasseter muscle and gingival tissue inflammatory response following treatment with high-fructose corn syrup in rats: Anti-inflammatory and antioxidant effects of kefiren_US
dc.typearticleen_US
dc.departmentAFSÜ, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümüen_US
dc.contributor.institutionauthorEkici, Ömer
dc.contributor.institutionauthorAslan, Esra
dc.contributor.institutionauthorAladağ, Tuğçe
dc.contributor.institutionauthorGüzel, Hilal
dc.contributor.institutionauthorPektaş, Mehmet Bilgehan
dc.identifier.doi10.1111/jfbc.13732
dc.relation.journalJournal Of Food Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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