Comparison of peripapillary vascular density as measured by optical coherence tomography angiography between various types of open-angle glaucoma

Abstract

Purpose: The purpose of this study is to compare the peripapillary vascular density in patients with various types of open-angle glaucoma (primary open-angle glaucoma, pseudoexfoliative glaucoma and pigmentary glaucoma) with healthy subjects by optic coherence tomography angiography (OCTA).Methods: Twenty-seven eyes with diagnosed POAG, thirty-four eyes with diagnosed PXG, twenty eyes with diagnosed PG and thirty eyes of healthy individuals were included in our study. Peripapillary vessel density measurements were performed with all images; (AI-DD), intra-disc (ID-DD) and peripapillary (PP-DD); measurement of vascular density in the radial peripapillary capillary network was performed by OCTA. The Kruskal-Wallis test and post-hoc test were performed for statistical analysis.Results: AI-DD was 50.76 +/- 2.07% in the healthy group, 47.12 +/- 2.57% in POAG, 39.71 +/- 6.64% in PXG, and 43.37 +/- 1.55% in PG. ID-DD was 50.49 +/- 3.74% in the healthy group, 49.51 +/- 6.83% in POAG, 38.42 +/- 13.46% in PXG, and 40.9 +/- 4.45% in PG. PP-DD was 51.26 +/- 3.12% in the healthy group, 50.13 +/- 3.04% in POAG, 42.31 +/- 7.31% in PXG, and 47.6 +/- 1.40% in PG. While it was found that all image and intra-disc vascular density measurements were statistically significantly lower in the PG and PXG group compared to the healthy group and the POAG (P<0.001), there was no significant difference between PXG and PG or between the control group and POAG.Conclusions: The lower radial peripapillary capillary density in PXG and PG compared to the POAG and healthy groups suggests that the blood flow around the optic disc is negatively affected in these patients.