The relationship between the systemic immune inflammatory index and computerized tomography guided coronary lesion severity in diabetic patients

Abstract

PurposeThe incidence of cardiovascular events is high in diabetic patients. In diabetic patients, the levels of inflammatory parameters in the circulation are increased, which is associated with poor outcome. In this study, we investigated the relationship between the systemic immune inflammatory index (SII), which is a sensitive indicator of the inflammatory response, and the severity of coronary atherosclerosis in diabetic patients.Materials and MethodsDiabetic patients who underwent coronary computed tomography for chest pain were included in the study. The patients were divided into two groups according to their median systemic immune inflammatory index values, and the predictors of SII elevation were investigated.ResultsA total 210 patients were included in the study. The mean age of the patients was 52.6 +/- 9.3 and 44.3% were male. In univariate analysis, HDL, triglyceride, lesion severity, and CAR were associated with high SII. In the regression analysis, lesion severity and lower HDL levels were determined as predictor of high SII.ConclusionInflammation plays an important role in the development of coronary atherosclerosis. Diabetic patients with elevated SII levels may require further investigation for significant atherosclerosis. Patient flow diagram. Enrollment and patients with available serum samples. Coronary CT is frequently used in the diagnosis and staging of coronary artery disease. The validation of coronary CT-based classifications and their relationship with other surrogate markers are not clear. In our study, we detected a close relationship between inflammation and coronary artery disease through coronary CT-based classification, which is quite interesting. image