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dc.contributor.authorTaşkan, Tuba
dc.contributor.authorTuran, Taylan
dc.contributor.authorDuvan, Candan
dc.contributor.authorGönenç, Aymelek
dc.date.accessioned2023-11-15T08:26:25Z
dc.date.available2023-11-15T08:26:25Z
dc.date.issued2023en_US
dc.identifier.citationTaşkan, T., Turan, T., Duvan, Z. C. İ., & Gönenç, A. (2023). Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. Turkish Journal of Obstetrics and Gynecology, 20(2), 113.en_US
dc.identifier.issn2149-9330
dc.identifier.urihttps://dx.doi.org/10.4274/tjod.galenos.2023.87936
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1759
dc.description.abstractObjective: Unexplained infertility refers to a diagnosis in which all standard examinations are usually normal and is statistically seen in approximately 30-40% of infertile couples and endometriosis encountered in 25-50% of patients with unexplained infertility. Unexplained infertility is thought to be closely associated with endometriosis and serum and peritoneal fluid levels of Fetuin-A is increased in patients with endometriosis. Fetuin-A is proposed as a diagnostic marker for endometriosis and has anti-inflammatory effects on several diseases. Oxidative stress also is central to the etiopathogenesis of infertility in women. The aim of this study was to evaluate serum Fetuin-A and oxidative stress parameter concentrations impact on unexplained infertility. Materials and Methods: In the study, serum Fetuin-A, IL-1β, CA I, TAS, TOS levels, and PON and ARE enzyme activities were measured using the Enzyme-Linked ImmunoSorbent Assay in the sera of diagnosed unexplained infertility females (n=44) and controls (n=41). Results: There was no statistically significant difference between unexplained infertile patients and control groups in terms of serum IL-1β, CA I, OSI, and PON levels (p>0.05). Serum Fetuin-A and ARE levels were significantly higher in unexplained infertility compared with the control, whereas serum TAS and TOS levels were lower (p<0.05, p<0.01, p<0.05, p<0.05, respectively). Conclusion: It is thought that increased Fetuin-A levels may be a response to the inflammatory process and increased ARE activity may be a sign of the impaired oxidant-antioxidant balance in unexplained infertility. This may contribute to the pathogenesis of infertility, and the data obtained will make a significant contribution to new works to be done in this sense.en_US
dc.language.isoengen_US
dc.publisherErkan Moren_US
dc.relation.isversionof10.4274/tjod.galenos.2023.87936en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffect of fetuin-a and oxidative stress on the occurrence of unexplained infertilityen_US
dc.typearticleen_US
dc.authorid0000-0003-1677-5356en_US
dc.departmentAFSÜen_US
dc.contributor.institutionauthorTaşkan, Tuba
dc.identifier.volume20en_US
dc.identifier.issue2en_US
dc.identifier.startpage113en_US
dc.identifier.endpage119en_US
dc.relation.journalTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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