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dc.contributor.authorCarman, Kürşat Bora
dc.contributor.authorGazeteci Tekin, Hande
dc.contributor.authorÇavuşoğlu, Dilek
dc.contributor.authorYarar, Coşkun
dc.contributor.authorKaplan, Emre
dc.contributor.authorArslan Karademir, Nil
dc.contributor.authorArslantaş, Didem
dc.date.accessioned2023-11-15T08:25:28Z
dc.date.available2023-11-15T08:25:28Z
dc.date.issued2023en_US
dc.identifier.citationÇarman, K. B., Tekin, H. G., Çavuşoğlu, D., Yarar, C., Kaplan, E., Karademir, C. N., & Arslantaş, D. (2023). Evaluation of MicroRNAs in Pediatric Epilepsy. Turkish Archives of Pediatrics, 58(4), 429-435.en_US
dc.identifier.issn2757-6256
dc.identifier.urihttps://dx.doi.org/10.5152/TurkArchPediatr.2023.22320
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1755
dc.description.abstractObjective: The pathophysiology of epilepsy remains unknown. Recent research has shown that microRNA expression changes in epileptic adults. In the present work, we aimed to identify serum microRNA expression in drug-responsive and resistant children with idiopathic general- ized epilepsy. Materials and Methods: The study included 43 (20 male and 23 female) epilepsy patients and 66 (43 male and 23 female) control subjects. The mean ages of the groups were 113.41 ± 61.83 and 105.46 ± 62.31 months, respectively. Twenty-eight epileptic patients were classi- fied as drug resistant. Thirteen of the controls were the siblings of patients with epilepsy. The study only included children with idiopathic generalized epilepsy who had normal brain mag- netic resonance imaging. The serum microRNA expressions (microRNA-181a, microRNA-155, microRNA-146, and microRNA-223) were investigated. Expressions of serum microRNA-181a, microRNA-155, microRNA-146, and microRNA-223 were previously investigated in epilepsy patients and children with febrile seizures. Therefore, these microRNAs were chosen. The expressions of serum levels of microRNAs were determined using quantitative real-time poly- merase chain reaction. Results: The results indicated that the expressions of serum microRNA-155 and microRNA-223 were elevated in epileptic children (P < .05). The expression of the same microRNAs was also elevated in individuals with drug-resistant epilepsy compared to healthy controls (P < .05). microRNA-146a, microRNA-155, and microRNA-223 expressions were higher in drug-resistant patients than in drug-responsive children (P < .05). A logistic regression study determined that an increase of microRNA-155 was a risk for epilepsy, while a decrease of microRNA-146a risk for epilepsy. Conclusion: Few researchers have investigated the function of microRNAs in the develop- ment of childhood epilepsy. Our findings revealed that epilepsy patients have abnormal microRNAexpression.en_US
dc.language.isoengen_US
dc.publisherAlpay Azapen_US
dc.relation.isversionof10.5152/TurkArchPediatr.2023.22320en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.title10.5152/TurkArchPediatr.2023.22320en_US
dc.typearticleen_US
dc.authorid0000-0003-4924-5300en_US
dc.departmentAFSÜen_US
dc.contributor.institutionauthorÇavuşoğlu, Dilek
dc.identifier.volume58en_US
dc.identifier.issue4en_US
dc.identifier.startpage429en_US
dc.identifier.endpage435en_US
dc.relation.journalTurkish archives of pediatrics (Online)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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