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dc.contributor.authorSarıkürkçü, Cengiz
dc.contributor.authorJeszka-Skowron, Magdalena
dc.contributor.authorÖzer, Mehmet Sabih
dc.date.accessioned2021-05-05T22:11:50Z
dc.date.available2021-05-05T22:11:50Z
dc.date.issued2020
dc.identifier.issn0926-6690
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2020.112273
dc.identifier.urihttps://hdl.handle.net/20.500.12933/174
dc.description2-s2.0-85080048828en_US
dc.description.abstractValeriana root extracts are used in herbal medicine for treating sleep disorders. There is a lack of information of phytochemical composition of Valeriana dioscoridis aerial parts’ extracts. The aim of the study was to measure antioxidant activity, determine the phenolic compounds from different groups such as phenolic acids and polyphenolic compounds: verbascoside or eriodictyol, and enzyme inhibitory activities in ethyl acetate, methanol and water extracts. The methanol extract showed the highest antioxidant activity almost in all assays (excluding ferrous ion chelating activity). Moreover, the concentrations of the determined phytochemicals mainly chlorogenic acid content (21.4 ± 0.7 mg/g), hesperidin (2.10 ± 0.05 mg/g) and protocatechuic acid (0.94 ± 0.02 mg/g) were the greatest for this extract. It was also the richest in all determined compounds – 21 phytochemicals were identified and water extract was the second most abundant in analytes (20 phytochemicals). The predominant compounds in water extract were the following: chlorogenic acid (20.3 ± 0.12 mg/g), protocatechuic acid (0.83 ± 0.02 mg/g) and caffeic acid (0.72 ± 0.01 mg/g). Protocatechuic acid was prevailing in ethyl acetate extract (0.59 ± 0.01 mg/g). In addition, in this extract the highest inhibitory activity of ?-amylase was found and the highest amount of verbascoside was determined in comparison to other extracts (0.53 ± 0.01 mg/g). The tyrosinase inhibitory effect especially of methanol extract was also shown. Pearson correlation confirmed that the strong biological activity of methanol extract from V. dioscoridis resulted mainly from its high content of chlorogenic acid. © 2020 Elsevier B.V.en_US
dc.description.sponsorship0911/SBAD/0382en_US
dc.description.sponsorshipThe authors are particularly grateful to Dr. Olcay Ceylan for his kind help in identifying the plant material used in this study. This work was supported by the Polish Ministry of Science and Higher Education (Grant No. 0911/SBAD/0382 ).en_US
dc.language.isoengen_US
dc.publisherElsevier B.V.en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectChlorogenic aciden_US
dc.subjectEnzyme inhibitory activityen_US
dc.subjectLC-MS/MSen_US
dc.subjectValeriana dioscoridisen_US
dc.titleValeriana dioscoridis aerial parts' extracts - A new source of phytochemicals with antioxidant and enzyme inhibitory activitiesen_US
dc.typearticleen_US
dc.departmentAFSÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü
dc.contributor.institutionauthorSarıkürkçü, Cengiz
dc.identifier.doi10.1016/j.indcrop.2020.112273
dc.identifier.volume148en_US
dc.relation.journalIndustrial Crops and Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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