Effect of platelet volume on mortality in maintenance hemodialysis patients

Abstract

OBJECTIVE: Hemodialysis is the most preferred type of renal replacement therapy in patients with end-stage renal disease. Knowing the parameters affecting mortality in patients receiving maintenance hemodialysis treatment may increase the survival rate in this patient group. Mean platelet volume (MPV) is one of the parameters of the complete blood count. It has been shown that high MPV can increase the mortality rate in many diseases. In this study, we aimed to investigate the effect of MPV on the mortality rate in maintenance hemodialysis patients. MATERIAL AND METHODS: The files of all patients who were started on maintenance dialysis treatment in our hospital between January 2010 and January 2020 were reviewed retrospectively. Demographic data and laboratory parameters of the patients were obtained from the patient files. For the MPV value, the mean of the MPV values in the routine complete blood count for the first 3 months after maintenance dialysis treatment was started. Patients who died and survived during the follow-up were compared in terms of MPV values. RESULTS: The study was conducted with 129 patients. 24.8% (n= 32) of the patients died during follow-up. MPV of deceased patients was significantly higher than survived patients (11.14±1 vs. 10.12±0.8, p<0.001). The best MPV value for predicting mortality was found to be 10.73 (with 75% sensitivity and 81.4% specificity). CONCLUSIONS: High MPV is an independent risk factor for mortality in maintenance hemodialysis patients. Tighter management of modifiable risk factors in hemodialysis patients with high MPV may improve their survival.