Evaluation of featured biochemical parameters and vitamin D in COVID-19

Abstract

Aim: We aimed to evaluate potential coagulation and inflammatory biomarkers. The recently discussed vitamin D levels predict the course ef the disease and determine the patients to be admitted to the intensive care unit in advance. Materials and Methods: This retrospective case-control study was conducted on 121 patients diagnosed and treated with COVID-19 disease, from March 2020 to June 2020 at the Amasya Sabuncuoğlu Şerefeddin Training and Research Hospital, Amasya, Turkey. D-dimer, Fibrinogen, Ferritin, and 25-OH Vitamin D levels that could be associated with COVID-19 infections were evaluated. The patients were divided into three groups: only Polymerase Chain Reaction positivity (PCR+), only Computerized Tomography positivity (CT+) and both PCR+ and CT+ among COVID-19 cases. Results: 121 patients with at mean age of 53 were investigated (52% male). Only CT+ cases were significantly older than other patients, p<0.001. D-dimer, Ferritin, and Fibrinogen levels were considerably higher in CT+ patients among all subjects, p =0.001, p =0.001, and p<0.001, respectively. There were no apparent differences in vitamin D levels between PCR+ and CT+ and others, CT+ and, PCR+ and others, p=0.277, p=0.350, p=0.397. However, we found that vitamin D levels were deficient in all groups. Conclusion: Since coagulopathy may accompany COVID-19, D-dimer and fibrinogen levels are predictive during admission. Serum ferritin demonstrates a potential risk factor for poor prognosis in COVID 19 patients.