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dc.contributor.authorKöseoğlu Toksoy, C.
dc.contributor.authorSarıtaş, Z. K.
dc.contributor.authorTürk Börü, Ü.
dc.contributor.authorZeytin Demiral, G.
dc.contributor.authorGörücü, F.
dc.contributor.authorBülbül, A.
dc.contributor.authorDemirel, H. H.
dc.contributor.authorKoç, Y.
dc.date.accessioned2023-10-17T13:02:03Z
dc.date.available2023-10-17T13:02:03Z
dc.date.issued2023en_US
dc.identifier.citationToksoy, C. K., SARITAŞ, Z., BÖRÜ, Ü., Demiral, G. Z., Görücü, F., Bülbül, A., ... & Koç, Y. (2023). Investigation of the protective effect of anzer propolis in cerebral ischemia-reperfusion injury. European Review for Medical & Pharmacological Sciences, 27(17).en_US
dc.identifier.issn2284-0729
dc.identifier.urihttps://dx.doi.org/10.26355/eurrev_202309_33560.
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1647
dc.description.abstractObjective: Globally, stroke is the leading cause of disability and death. With the use of thrombolytic therapy, reperfusion injury, and its consequences came to the fore. We aimed to find out how anzer propolis, which can only be obtained in Turkey's Eastern Black Sea region, affected ischemia-reperfusion injury using biochemical and histological techniques. Materials and methods: 32 female Wistar albino rats were divided into 4 groups, including a control group. Three of the groups underwent 30 minutes of induced ischemia via clamping of the common carotid artery, followed by ischemia-reperfusion injury through the release of the clamp. One group received no treatment, another received oral administration of 100 mg/kg of anzer propolis one hour before surgery, and the third group received oral administration of 40 mg/kg of acetylsalicylic acid just before surgery. Histopathological examination assessed apoptosis and tissue necrosis, while serum and brain tissue were evaluated for levels of nerve growth factor (NGF), Interlokin 1β (IL-1β), Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), total antioxidant capacity (TAS), and total oxidant capacity (TOS). Results: Anzer propolis and acetylsalicylic acid significantly reduced hyperemia in vessels, vacuolization in neurons, glial cell infiltration, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positivity. The anzer propolis group had the highest NGF levels. The anzer propolis and acetylsalicylic acid groups had lower levels of TNF-a and IL-6 in the brain tissue than the ischemia-reperfusion group, while TAS levels were higher. Conclusions: The findings obtained in this study suggest that anzer propolis has a neuroprotective effect against ischemia-reperfusion injury and will have beneficial effects on neurodegeneration. We believe our findings will contribute to the clinical treatment of ischemia-reperfusion injury.en_US
dc.language.isoengen_US
dc.publisherVerducien_US
dc.relation.isversionof10.26355/eurrev_202309_33560.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStrokeen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectAnzer Propolisen_US
dc.titleInvestigation of the protective effect of anzer propolis in cerebral ischemia-reperfusion injuryen_US
dc.typearticleen_US
dc.authorid0000-0002-9224-9203en_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.contributor.institutionauthorKöseoğlu Toksoy, Cansu
dc.identifier.volume27en_US
dc.identifier.issue17en_US
dc.identifier.startpage8004en_US
dc.identifier.endpage8012en_US
dc.relation.journalEuropean review for medical and pharmacological sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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