| dc.contributor.author | Sarıkürkçü, Cengiz | |
| dc.contributor.author | Özer, Mehmet Sabih | |
| dc.contributor.author | İstifli, Erman Salih | |
| dc.contributor.author | Şahinler, Saliha Şeyma | |
| dc.contributor.author | Tepe, Bektaş | |
| dc.date.accessioned | 2021-05-05T22:11:50Z | |
| dc.date.available | 2021-05-05T22:11:50Z | |
| dc.date.issued | 2021 | |
| dc.identifier.issn | 0254-6299 | |
| dc.identifier.uri | https://doi.org/10.1016/j.sajb.2021.03.020 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12933/160 | |
| dc.description | 2-s2.0-85103331629 | en_US |
| dc.description.abstract | Sideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant and enzyme inhibitory activities of solvent extracts of S. leptoclada O. Schwarz & P.H. Davis, an endemic species. It was determined that methanol (MeOH) and water extracts contained high amounts of chlorogenic acid and verbascoside, while the ethyl acetate (EtOAc) extract contained high amounts of 4-hydroxybenzoic and vanilic acids. The water extract showed the highest antioxidant activity in almost all parameters. Inhibitory activity of the MeOH extract on tyrosinase was 1.04 mg/ml, which was the highest value in this experiment. On the other hand, in ?-amylase inhibitory assay, the EtOAc extract showed an activity of 2.21 mg/ml. Docking analysis showed that verbascoside can be an effective tyrosinase and ?-amylase inhibitory agent. © 2021 SAAB | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Elsevier B.V. | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Antioxidant activity | en_US |
| dc.subject | Phytochemical composition | en_US |
| dc.subject | Sideritis leptoclada | en_US |
| dc.subject | Tyrosinase inhibitory | en_US |
| dc.subject | ?-Amylase inhibitory | en_US |
| dc.title | Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey | en_US |
| dc.type | article | en_US |
| dc.department | AFSÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü | |
| dc.contributor.institutionauthor | Sarıkürkçü, Cengiz | |
| dc.identifier.doi | 10.1016/j.sajb.2021.03.020 | |
| dc.relation.journal | South African Journal of Botany | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.department-temp | Sarikurkcu, C., Faculty of Pharmacy, Afyonkarahisar Health Sciences University, Afyonkarahisar, TR-03100, Turkey; Ozer, M.S., Faculty of Science and Literature, Manisa Celal Bayar UniversityManisa TR-45140, Turkey; Istifli, E.S., Faculty of Science and Literature, Cukurova UniversityAdana TR-01330, Turkey; Sahinler, S.S., Faculty of Pharmacy, Afyonkarahisar Health Sciences University, Afyonkarahisar, TR-03100, Turkey; Tepe, B., Faculty of Science and Literature, Kilis 7 Aralik UniversityKilis TR-79000, Turkey | en_US |
