Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorKundakcı, Yunus Emre
dc.contributor.authorBilir, Abdulkadir
dc.contributor.authorAtay, Emre
dc.contributor.authorVurmaz, Ayhan
dc.contributor.authorFirat, Fatma
dc.contributor.authorArıkan, Evrim Suna
dc.date.accessioned2023-09-26T11:38:06Z
dc.date.available2023-09-26T11:38:06Z
dc.date.issued2023en_US
dc.identifier.citationKundakci, Y. E., Bilir, A., Atay, E., Vurmaz, A., Firat, F., & Arikan, E. S. (2023). Protective Effects of Different Doses of Ginsenoside-Rb1 Experimental Cataract Model that in Chick Embryos. Current Eye Research, (just-accepted), 1-13.en_US
dc.identifier.issn1460-2202
dc.identifier.urihttps://dx.doi.org/10.1080/02713683.2023.2221415.
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1609
dc.description.abstractPurpose: There has been increased interest in phytochemical antioxidants to prevent protein damage and aggregate formation in cataract treatment. In this study, the protective effect of different doses of Rb1 (GRb1), one of the ginsenosides of Panax Ginseng, in the experimental cataract model formed in chick embryos was investigated. Methods: Five different experimental groups were formed with 100 SPF fertilized eggs: Control (0.9% NaCl to physiological saline), hydrocortisone hemisuccinate sodium (HC), low dose (HC + L-GRb1 (1 mg/kg)), medium dose (HC+). M-GRb1 (2.5 mg/kg)), and high dose (HC + H-GRb1 (5 mg/kg)). All solutions were given to air sack at 15 days of incubation. On the 17th day, the bulbous oculi of the chick embryos were dissected. Cataract formations of the lenses, glutathione (GSH), malondialdehyde (MDA), total antioxidant (TAS), total oxidant (TOS) levels, Caspase-3 H-score, and TUNEL index were determined. In addition, crystalline alpha A (CRYAA) gene expression was evaluated. Results: Cataracts were observed in the control, HC, HC + L-GRb1, HC + M-GRb1, and HC + H-GRb1 groups with a frequency of 0%, 100%, 75%, 56.25%, and 100%, respectively. There were statistically significant differences between the control and HC groups in terms of TAS, TOS, MDA, GSH, Caspase-3 H-score, and TUNEL index (p < .05). When the therapeutic effect of the GRb1 groups was evaluated, the HC group showed significant differences with the HC + L-GRb1 and HC + M-GRb1 groups in almost all parameters (p < .05), while there was no statistical difference with the HC + H-GRb1 group (p > .05). In addition, gene expression levels differed between the groups, although not statistically significant (p > .05). Conclusion: 1 mg/kg and 2.5 mg/kg GRb1 applications show therapeutic properties on the HC-induced cataract model. This effect is more pronounced at 2.5 mg/kg.en_US
dc.language.isoengen_US
dc.publisherIRL Pressen_US
dc.relation.isversionof10.1080/02713683.2023.2221415.en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectCataracten_US
dc.subjectGinsenoside-Rb1 (GRb1)en_US
dc.subjectPanax Ginsengen_US
dc.subjectChicken Embryoen_US
dc.subjectLensen_US
dc.titleProtective effects of different doses of ginsenoside-Rb1 experimental cataract model that in chick embryosen_US
dc.typearticleen_US
dc.authorid0000-0003-0925-5723en_US
dc.departmentAFSÜ, Atatürk Sağlık Hizmetleri Meslek Yüksekokulu, Fizyoterapi Bölümüen_US
dc.contributor.institutionauthorKundakcı, Yunus Emre
dc.contributor.institutionauthorBilir, Abdülkadir
dc.contributor.institutionauthorAtay, Emre
dc.contributor.institutionauthorVurmaz, Ayhan
dc.contributor.institutionauthorFırat, Fatma
dc.contributor.institutionauthorArıkan, Evrim Suna
dc.identifier.volume48en_US
dc.identifier.issue9en_US
dc.identifier.startpage817en_US
dc.identifier.endpage825en_US
dc.relation.journalCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster