The effects of curcumin on mechanical functions and cardiac contractility in isolated rat hearts
MetadataShow full item record
CitationKutlay, Ö., Kaygısız, B., & Aktan, A. K. (2023). The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. Türk Kardiyoloji Derneği Arşivi, 51(4).
Objective: Curcumin is a bioactive compound that has well-known pharmacological activities. Numerous studies have shown that curcumin provides potential cardiovascular beneﬁts through a variety of mechanisms.The present study aims to discuss diﬀerent concentrations of curcumin's impact on mechanical functions and cardiac contractility in isolated perfused rat hearts. Methods: The hearts were isolated under sodium thiopental (50 mg/kg) anesthesia and perfused with a modiﬁed Krebs-Henseleit solution (mK-Hs). After stabilization, curcumin was applied in concentrations of 0.1, 1, and 10 µM. In isolated rat hearts, indexes of + dP / dt max, LVDP, MAP, and LVEDP were evaluated for cardiac contractility and ventricular function. Results: All curcumin concentrations reduced +dP/dtmax and LVDP. Ten µM curcumin also signiﬁcantly decreased heart rate. Curcumin (1 and 10 µM) increased LVEDP and reduced MAP amplitude with a concomitant increase in MAP duration. Curcumin at all concentrations did not aﬀect dMAPdtmax and dMAPdtmin. Conclusion: Our results might suggest that curcumin at higher concentrations (≥ 1 µM) increases LVEDP with a negative chronotropic eﬀect and decreases MAP amplitude with an increase in MAP duration. There is suﬃcient evidence from this study that Curcumin possesses an adverse inotropic action. Diﬀerent disease models should support the pathophysiological role of Curcumin on cardiac contraction.