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dc.contributor.authorAlmuradova, Elvina
dc.contributor.authorYalcin, Suayib
dc.contributor.authorArıkan, Rukiye
dc.contributor.authorAyhan, Murat
dc.contributor.authorDemir, Hacer
dc.contributor.authorÇevik, Gökçen Tuğba
dc.contributor.authorKaraca, Mustafa
dc.contributor.authorPetekkaya, İbrahim
dc.contributor.authorKarabulut, Bülent
dc.date.accessioned2023-09-22T11:53:53Z
dc.date.available2023-09-22T11:53:53Z
dc.date.issued2023en_US
dc.identifier.citationAlmuradova, E., Yalcin, S., Arıkan, R., Ayhan, M., Demir, H., Cevik, G. T., ... & ALMURADOVA, E. (2023). Survival of Patients With Metastatic Rectum Cancer Who Underwent Metastasectomy Following Conversion Chemotherapy Sans Pelvic Radiotherapy: A Turkish Oncology Group Study. Cureus, 15(5).en_US
dc.identifier.issn2168-8184
dc.identifier.urihttps://dx.doi.org/10.7759/cureus.39119.
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1595
dc.description.abstractBackground: The management of early rectal cancer is different from that of colon cancer in terms of radiotherapy (RT) requirements or neoadjuvant treatment. It is not clear how the course of rectal cancer differs from that of the colon in a metastatic setting or how it should be approached differently. This study aimed to evaluate outcomes after combining downsizing chemotherapy (CTx) with rescue surgery. Methods: Eighty-nine patients (57 men and 32 women) diagnosed with metastatic rectal cancer with resectable disease after systemic CTx were included in the study. All patients underwent surgery for the primary mass and metastasis, but none received radiation therapy before or after surgery. Survival curves for overall survival (OS) and progression-free survival (PFS) were generated using the Kaplan-Meier method and compared with the log-rank test for subgroups. Results: The median follow-up time was 28.8 (17.6-39.4) months. During the follow-up, 54 (60.7%) patients died and 78 (87.6%) patients had a PFS event. Cancer relapsed in 72 (80.9%) patients. Median OS was 35.2 (95% CI: 28.5-41.8) months, and median PFS was 17.7 (95% CI: 14.4-21) months. The five-year OS and PFS were 19% and 3.5%, respectively. Male sex (p=0.04) and a better Mandard score (p=0.021) were associated with a longer OS, while obesity was associated with a shorter PFS (p<0.001). Conclusion: Our study is the first to evaluate the effects of metastasectomy after conversion therapy in metastatic rectal cancer independent of colon cancer. As a result of the study, it was seen that the survival after metastasectomy in rectal cancer is worse than the colon cancer data known from previous studies.en_US
dc.language.isoengen_US
dc.publisherCA : Cureusen_US
dc.relation.isversionof10.7759/cureus.39119.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChemotherapyen_US
dc.subjectMetastasectomyen_US
dc.subjectMetastaticen_US
dc.subjectRadiotherapyen_US
dc.subjectRectum Canceren_US
dc.titleSurvival of patients with metastatic rectum cancer who underwent metastasectomy following conversion chemotherapy sans pelvic radiotherapy: a Turkish oncology group studyen_US
dc.typearticleen_US
dc.authorid0000-0003-1235-9363en_US
dc.departmentAFSÜen_US
dc.contributor.institutionauthorDemir, Hacer
dc.identifier.volume15en_US
dc.identifier.issue5en_US
dc.relation.journalCurēusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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