Browsing by Author "İstifli, Erman Salih"
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Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey
Sarıkürkçü, Cengiz; Özer, Mehmet Sabih; İstifli, Erman Salih; Şahinler, Saliha Şeyma; Tepe, Bektaş (Elsevier B.V., 2021)Sideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant ... -
Cytotoxic and genotoxic evaluation of copper oxychloride through Allium test and molecular docking studies
Liman, Recep; Ali, Muhammad Muddassir; Ciğerci, İbrahim Hakkı; İstifli, Erman Salih; Sarıkürkçü, Cengiz (Springer, 15.04.2021)Copper oxychloride gained great importance due to its broad-spectrum antifungal action to combat various fungal diseases of plants. However, excess quantity of cupric fungicides on plants causes enzymatic changes and toxic ... -
Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols
İstifli, Erman Salih; Şıhoğlu Tepe, Arzuhan; Netz, Paulo A.; Sarıkürkçü, Cengiz; Kılıç, İbrahim Halil; Tepe, Bektaş (Scientific and Technical Research Council of Turkey, 30.08.2021)The novel coronavirus (COVID-19, SARS-CoV-2) is a rapidly spreading disease with a high mortality. In this research, the interactions between specific flavonols and the 2019-nCoV receptor binding domain (RBD), transmembrane ... -
In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties
İstifli, Erman Salih; Netz, Paulo A.; Şıhoğlu Tepe, Arzuhan; Hüsunet, Mehmet Tahir; Sarıkürkçü, Cengiz; Tepe, Bektaş (Taylor & Francis Inc, 2020)Coronavirus Disease 2019 (COVID-19) has infected more than thirty five million people worldwide and caused nearly 1 million deaths as of October 2020. The microorganism causing COVID-19 was named as Severe Acute Respiratory ... -
Interaction of certain monoterpenoid hydrocarbons with the receptor binding domain of 2019 novel coronavirus (2019-nCoV), transmembrane serine protease 2 (TMPRSS2), cathepsin B, and cathepsin L (CatB/L) and their pharmacokinetic properties
İstifli, Erman Salih; Şıhoğlu Tepe, Arzuhan; Sarıkürkçü, Cengiz; Tepe, Bektaş (Tubitak Scientific & Technical Research Council Turkey, 2020)As of June 2020, the coronavirus disease 19 (COVID-19) caused by the 2019 new type coronavirus (2019-nCoV) infected more than 7,000,000 people worldwide and caused the death of more than 400,000 people. The aim of this ... -
Molecular interactions of some phenolics with 2019-nCoV and related pathway elements
İstifli, Erman Salih; Şıhoğlu Tepe, Arzuhan; Sarıkürkçü, Cengiz; Tepe, Bektaş (Pamukkale University, 2021)As of June 2021, the novel coronavirus disease (SARS-CoV-2) resulted in 180 million cases worldwide and resulted in the death of approximately 4 million people. However, an effective pharmaceutical with low side effects ... -
Two endemic Onosma species (O. sieheana and O. stenoloba): A comparative study including docking data on biological activity and phenolic composition
Sarıkürkçü, Cengiz; Şahinler, Saliha Şeyma; Hüsunet, Mehmet Tahir; İstifli, Erman Salih; Tepe, Bektaş (Elsevier, 2020)There are convincing evidences that species belonging to the Onosma genus have been used in the treatment of various diseases for centuries. In this study, antioxidant and tyrosinase and a-amylase inhibitory activities of ... -
Understanding the molecular interaction of SARS-CoV-2 spike mutants with ACE2 (angiotensin converting enzyme 2)
İstifli, Erman Salih; Netz, Paulo A.; Şıhoğlu Tepe, Arzuhan; Sarıkürkçü, Cengiz; Tepe, Bektaş (Taylor & Francis Group, 08.09.2021)Covid-19 is a viral disease caused by the virus SARS-CoV-2 that spread worldwide and caused more than 4.3 million deaths. Moreover, SARS-CoV-2 still continues to evolve, and specifically the E484K, N501Y, and South Africa ...
