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Design, semi-synthesis and examination of new gypsogenin derivatives against leukemia via Abl tyrosine kinase inhibition and apoptosis induction

Ulusoy, Nafia Gökçe; Emirdağ, Safiye; Sözer, Ece; Radwan, Mohamed O.; Çiftçi, Halil İbrahim; Aksel, Mehran; Şahin Bölükbaşı, Serap; Özmen, Ali; Yaylı, Nurettin; Karayıldırım, Tamer; Alankuş, Özgen; Tateishi, Hiroshi; Otsuka, Masami; Fujita, Mikako; Sever, Belgin (Elsevier, 01.10.2022)

Chronic myelogenous leukemia (CML) is characterized by Philadelphia translocation arising from Bcr-Abl fusion gene, which encodes abnormal oncoprotein showing tyrosine kinase (TK) function. Certain mutations in kinase ...