ORCID "0000-0001-5094-2520" için listeleme
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Bioactive constituents, antioxidant effects and enzyme inhibitory properties of two Onosma species (Onosma trapezuntea and O. rigidum)
Kırkan, Bülent; Sarıkürkçü, Cengiz; Zengin, Gökhan (Elsevier, 2022)The genus Onosma is the biggest genus in the family Boraginaceae and its members are widely used for traditional purposes in several countries folk medicine. In the current work, two Onosma (O. trapezuntea and O. rigidum) ... -
Can Acanthus spinosus be used as an alternative antioxidant and enzyme inhibitory agent?
Sarıkürkçü, Cengiz; Kırkan, Bülent; Şahinler, Saliha Şeyma; Tepe, Bektaş (Elsevier, 2022)Plant polyphenols attract researchers because of their bioactive properties. In this study, the chemical compositions and in vitro antioxidant and enzyme inhibitory activities of ethyl acetate (EtOAc), methanol (MeOH), and ... -
Cytotoxic and genotoxic evaluation of copper oxychloride through Allium test and molecular docking studies
Liman, Recep; Ali, Muhammad Muddassir; Ciğerci, İbrahim Hakkı; İstifli, Erman Salih; Sarıkürkçü, Cengiz (Springer, 15.04.2021)Copper oxychloride gained great importance due to its broad-spectrum antifungal action to combat various fungal diseases of plants. However, excess quantity of cupric fungicides on plants causes enzymatic changes and toxic ... -
Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols
İstifli, Erman Salih; Şıhoğlu Tepe, Arzuhan; Netz, Paulo A.; Sarıkürkçü, Cengiz; Kılıç, İbrahim Halil; Tepe, Bektaş (Scientific and Technical Research Council of Turkey, 30.08.2021)The novel coronavirus (COVID-19, SARS-CoV-2) is a rapidly spreading disease with a high mortality. In this research, the interactions between specific flavonols and the 2019-nCoV receptor binding domain (RBD), transmembrane ... -
Draba cemileae (Karaer): Phytochemical composition, antioxidant and enzyme inhibitory activity
Cüce, Mustafa; Demir, Ersin; Şıhoğlu Tepe, Arzuhan; Sarıkürkçü, Cengiz (Elsevier, 2022)Plant polyphenols have always attracted the attention of researchers with their excellent biological activity potentials. In this study, roots, leaves and seeds of Draba cemileae (Karaer) were evaluated for their chemical ... -
Element concentration, daily intake of elements, and health risk indices of wild mushrooms collected from Belgrad Forest and Ilgaz Mountain National Park (Turkey)
Keskin, Feyyaz; Sarıkürkçü, Cengiz; Akata, Ilgaz; Tepe, Bektaş (Springer, 13.05.2021)The aim of this study was to determine the element content of wild edible and inedible mushroom species (Agaricus campestris, Armillaria ostoyae, Boletus reticulatus, Bondarzewia mesenterica, Bovistella utriformis, ... -
LC-MS/MS analyses and biological activities of Onosma sintenisii and O. mutabile
Özer, Mehmet Sabih; Sencan, Kemal Erdem; Sarıkürkcü, Cengiz; Tepe, Bektaş (İzzet KARA, 2022)This study was aimed to investigate the chemical compositions, in vitro antioxidant and enzyme inhibitory activities of methanol extracts from O. sintenisii and O. mutabile. Spectrophotometric analyzes showed that the total ... -
LC-MS/MS Profiles and In Vitro Biological Activities of Extracts of an Endemic Species from Turkey: Stachys cretica ssp. anatolica
Carev, Ivana; Sarıkürkçü, Cengiz (MDPI, 25.05.2021)Background: Genus Stachys is one of the largest of the Lamiaceae family, having around 300 different plant species inhabiting areas with temperate and warm climates. The Stachys species in Turkey are represented with 81 ... -
Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS) Identification of Phytochemicals and the Effects of Solvents on Phenolic Constituents, Antioxidant Capacity, Skin-Whitening and anti-Diabetic Activity of Onosma mitis
Tlili, Nizar; Sarıkürkçü, Rıfat Tayyib; Özer, Mehmet Sabih; Sarıkürkçü, Cengiz (Taylor & Francis Group, 24.05.2021)To the best of our knowledge, this is the first study on the effect of solvent (water, methanol, and ethyl acetate) upon phenolics extracted from Onosma mitis. The antioxidant capacities together with the enzyme inhibitory ... -
Minerals, phenolics, and biological activity of wild edible mushroom, Morchella steppicola Zerova
Sarıkürkçü, Cengiz; Solak, Mehmet Halil; Tarkowski, Petr; Zeljković, Sanja Ćavar (Taylor & Francis Group, 12.03.2022)Tasteful morels (Morchella sp.) are one of the most popular mushrooms, both economically and scientifically. Due to their beneficial constituents, they are classified as functional foods. This study focuses on the chemical ... -
Molecular interactions of some phenolics with 2019-nCoV and related pathway elements
İstifli, Erman Salih; Şıhoğlu Tepe, Arzuhan; Sarıkürkçü, Cengiz; Tepe, Bektaş (Pamukkale University, 2021)As of June 2021, the novel coronavirus disease (SARS-CoV-2) resulted in 180 million cases worldwide and resulted in the death of approximately 4 million people. However, an effective pharmaceutical with low side effects ... -
Nutraceutical extracts from some endemic Onosma (O. circinnata, O. bornmuelleri, and O. angustissima) species: LC–ESI-MS/MS–based polyphenol profile, antioxidant and enzyme inhibition activities
Sarıkürkçü, Cengiz; Şahinler, Saliha Şeyma; Özer, Mehmet Sabih; Şıhoğlu Tepe, Arzuhan (Wiley, 18.06.2021)This study aimed to determine the chemical composition of methanol extracts from Onosma circinnata, Onosma bornmuelleri, and Onosma angustissima and to investigate their antioxidant and enzyme inhibitory activities. ... -
Onosma inexspectata and Onosma armenum as Novel Sources of Phytochemicals with Determination by High-Performance Liquid Chromatography–Mass Spectrometry (HPLC-MS/MS) with Evaluation of the Antioxidant and Enzyme Inhibitory Capacities
Sarıkürkçü, Cengiz; Tlili, Nizar (Taylor & Francis Group, 20.10.2021)The goal of the current work was to study the phytochemical content of Onosma inexspectata Teppner and O. armenum DC. The antioxidant properties using six assays and the enzyme inhibitory capacities against α-amylase, ... -
Onosma polyantha vs. Onosma mollis: Analysis of Phenolic Compounds Using Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS) and Assessment of the Antioxidant Activity
Tlili, Nizar; Sarıkürkçü, Rıfat Tayyib; Olcay, Ceylan; Sarıkürkçü, Cengiz (Bellwether Publishing, Ltd., 2021)To our knowledge, this is the first work on the influence of species upon the bioactive molecules, antioxidant properties, and enzyme inhibitory capacities against tyrosinase and α-amylase of Onosma polyantha and O. mollis. ... -
Phenolic profile, antioxidant and enzyme inhibitory activity of the ethyl acetate, methanol and water extracts of Capparis spinosa L.
Kırkan, Bülent; Olcay, Ceylan; Sarıkürkçü, Cengiz; Tepe, Bektaş (Pamukkale University, 2021)In this study, it was aimed to determine the phytochemical compositions and biological activities of ethyl acetate (EtOAc), methanol (MeOH) and water extracts obtained from the aerial parts of Capparis spinosa L. As a ... -
Phytochemical Analysis and Biological Evaluation of Two Endemic Onosma Species (Onosma cappadocica and O. rutilum)
Kırkan, Bülent; Sarıkürkçü, Cengiz; Şıhoğlu Tepe, Arzuhan (AMG Transcend Association, 12.02.2022)Onosma species have been used by the public for centuries to treat various diseases. This study aimed to analyze the chemical composition, antioxidant, and enzyme inhibitory activity potentials of the methanol extracts of ... -
Phytochemical analysis, antioxidant, and antimicrobial activities of ducrosia flabellifolia: A combined experimental and computational approaches
Snoussi, Mejdi; Ahmad, Iqrar; Aljohani, Abdullah M A; Patel, Harun; Abdulhakeem, Mohammad A; Alhazmi, Yasser S; Tepe, Bektas; Adnan, Mohd; Siddiqui, Arif J; Sarikurkcu, Cengiz; Riadh, Badraouni; Feo, Vincenzo De; Alreshidi, Mousa; Noumi, Emira (MDPI AG, 2022)Ducrosia flabellifolia Boiss. is a rare desert plant known to be a promising source of bioactive compounds. In this paper, we report for the first time the phytochemical composition and biological activities of D. flabellifolia ... -
Phytochemical Composition, Antioxidant, and Enzyme Inhibition Activities of Methanolic Extracts of Two Endemic Onosma Species
Kandasamy, Saravanakumar; Sarıkürkçü, Cengiz; Şahinler, Saliha Şeyma; Sarıkürkçü, Rabia Büşra; Wang, Myeong-Hyeon (MDPI, 05.07.2021)Onosma species have been used as a dye for hundreds of years due to their dark red pigments. These species have also been used by mankind in the treatment of various diseases since ancient times. This work analyzed the ... -
Two Onosma Species (Onosma microcarpum and O. nana) as an Alternative Source of Multifunctional Agents: Biological and Phytochemical Evaluation
Kırkan, Bülent; Sarıkürkçü, Cengiz; Binzet, Rıza; Tepe, Bektaş (AMG Transcend Association, 06.02.2022)Phytochemicals have significant biological effects. This study aimed to investigate the chemical composition, antioxidant and inhibitory activities of methanol (MeOH) extracts obtained from the aerial parts of Onosma ... -
Understanding the molecular interaction of SARS-CoV-2 spike mutants with ACE2 (angiotensin converting enzyme 2)
İstifli, Erman Salih; Netz, Paulo A.; Şıhoğlu Tepe, Arzuhan; Sarıkürkçü, Cengiz; Tepe, Bektaş (Taylor & Francis Group, 08.09.2021)Covid-19 is a viral disease caused by the virus SARS-CoV-2 that spread worldwide and caused more than 4.3 million deaths. Moreover, SARS-CoV-2 still continues to evolve, and specifically the E484K, N501Y, and South Africa ...