Yazar "Varol, Nuray" için listeleme
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Boron ameliorates arsenic-induced DNA damage, proinflammatory cytokine gene expressions, oxidant/antioxidant status, and biochemical parameters in rats
İnce, Sinan; Küçükkurt, İsmail; Acaröz, Ulaş; Arslan Acaröz, Damla; Varol, Nuray (Wiley, 2019)Arsenic, an element found in nature, causes hazardous effects on living organisms. Meanwhile, natural compounds exhibit protective effects against hazardous substances. This study evaluated the effects of boron against ... -
Boron, a Trace Mineral, Alleviates Gentamicin-Induced Nephrotoxicity in Rats
İnce, Sinan; Küçükkurt, İsmail; Demirel, Hasan Hüseyin; Arslan-Acaröz, Damla; Varol, Nuray (Humana Press Inc, 2020)The present study was considered to assess the protective effects of boron (B) on gentamicin-induced oxidative stress, proinflammatory cytokines, and histopathological changes in rat kidneys. Rats were split into eight ... -
THE EFFECT OF HEAT SHOCK PROTEIN 90 INHIBITORS ON HISTONE 4 LYSINE 20 METHYLATION IN BLADDER CANCER
Çoban, Nuran; Varol, Nuray (Excli Journal Managing Office, 2019)Heat shock protein 90 (HSP90), an ATP-dependent molecular chaperone required for the stability and function of numerous oncogenic signaling, is one of the hallmarks of cancer. Recent years, the studies showed that HSP90 ... -
Eksozomal inhibitörlerin epigenetik regülasyondaki rolü
Durgut, Şeyma Gül (Afyonkarahisar Sağlık Bilimleri Üniversitesi, 2022)DNA metilasyonu, epigenetik gen düzenlenmesinin temel mekanizmalarından biri olup en iyi bilinen epigenetik modifikasyondur. Bu epigenetik modifikasyon, DNA metiltransferazlar (DNMT'ler) tarafından katalize edilir ve ... -
GELDANAMİSİN VE TRİKOSTATİN A’NIN İNSAN MESANE KANSERİ HÜCRELERİ ÜZERİNE SİNERJİSTİK ETKİSİ
Varol, Nuray; Çoban, Nuran (2018)AMAÇ: Isı şok protein 90 (IŞP), ATP-bağımlı moleküler bir şaperon olup kanserin temel özellikleri olarak tanımlanan çok sayıdaki onkogenik sinyal proteinlerinin stabilitesi ve fonksiyonu için gereklidir. Bu nedenle, IŞP90 ... -
Konvansiyonel Kemoterapötikler ve Isı Şok Protein 90 İnhibitör Kombinasyonunun Mesane Kanseri Hücreleri Üzerine Apoptotik Etkisi
Varol, Nuray (2019)Amaç Isı şok protein 90 (IŞP90), ATP-bağımlı moleküler şaperonlardır ve hücresel fonksiyonların gerçekleştirilmesinden sorumlu çok sayıda önemli proteinin konformasyonel katlanması ve stabilizasyonu için gereklidir. Bu ... -
Methylation analysis of histone 4-related gene HIST1H4F and its effect on gene expression in bladder cancer
Varol, Nuray; Keleş, İbrahim; Yıldız, Handan; Karaosmanoğlu, Cem; Karalar, Mustafa; Zengin, Kürşad; Sarıcı, Hasmet; Tokyol, Çiğdem (Elsevier/North-Holland, 2023)Recently, aberrant DNA methylation of the HIST1H4F gene (encodes Histone 4 protein) has been shown in many types of cancer, which may serve as a promising biomarker for early cancer diagnosis. However, the correlation ... -
Proteomic analysis of the anticancer effect of various extracts of endemicThermopsis turcica in human cervical cancer cells
Yıldız, Mustafa; Terzi, Hakan; Yıldız, Saliha Handan; Varol, Nuray; Özdemir Erdoğan, Müjgan; Kasap, Murat; Akçalı, Nermin; Solak, Mustafa (Turkiye Klinikleri, 2020)Background/aim: Thermopsis turcica is a perennial species endemic to Turkey and different extracts of T. turcica have an antiproliferative effect on cancer cells, but there has not been any report on HeLa (human cervical ... -
Relationship between expression levels of TDRD7 and CRYBB3 and development of age-related cortico-nuclear cataracts
Yildiz, Saliha Handan; Karaosmanoglu, Cem; Duman, Rahmi; Varol, Nuray; Erdogan, Muejgan Ozdemir; Solak, Mustafa; Duman, Resat (Springernature, 2023)BackgroundThe human lens develops age-related cataracts (ARCs) because of the complicated effects of aging and stressful conditions. Under conditions involving oxidative stress, cells form stress granules (SGs). TDRD7 has ... -
Relationship between expression levels of TDRD7 and CRYBB3 and development of age-related cortico-nuclear cataracts (vol 24, 16, 2023)
Yildiz, Saliha Handan; Karaosmanoglu, Cem; Duman, Rahmi; Varol, Nuray; Erdogan, Muejgan Ozdemir; Solak, Mustafa; Duman, Resat (Springernature, 2023)[Abstract Not Available] -
Relationship between SIRT1 gene expression level and disease in age-related cataract cases
Ağaoğlu, Nihat Buğra; Varol, Nuray; Yıldız, Saliha Handan; Karaosmanoğlu, Cem; Duman, Rahmi; Özdemir Erdoğan, Müjgan; Solak, Mustafa (2019)Background/aim: Age-related cataract is the most important visual impairment all over the world. Epigenetic modifications, especially overexpression of histone deacetylases, have become the focus of interest for cataract ... -
Sıçanlarda Akrilamid ile İndüklenen Oksidatif Strese Karşı Taurinin Koruyucu Etkisi
İnce, Sinan; Acaröz, Ulaş; Arslan Acaröz, Damla; Varol, Nuray; Gürler, Zeki; Küçükkurt, İsmail; Demirel, Hasan Hüseyin; Eryavuz, Abdullah (2018)Bu çalışmada, sıçanlarda akrilamid ile oluşturulan oksidatif strese karşı antioksidan ajan olan taurinin koruyucu etkisinin araştırılması amaçlandı. Toplam 35 Wistar erkek sıçan standart rodent yemiyle beslendi ve 5 eşit ...
