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CARWL score as a predictor of radiation-induced periodontitis in locally advanced head and neck cancer undergoing concurrent chemoradiotherapy
Bascil, Sibel; Somay, Efsun; Durankus, Nilufer Kilic; Senyurek, Sukran; Ozturk, Duriye; Selek, Ugur; Topkan, Erkan (Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2025)Although concurrent chemoradiotherapy (CCRT) has improved outcomes in locally advanced head and neck cancer (LA-HNC), radiation-induced periodontitis (RIP) remains an under-recognized oral toxicity with significant ... -
Comment on: Risk prediction of complicated course in patients undergoing major head and neck surgery with free fl ap reconstruction
Topkan, Erkan; Somay, Efsun; Ozturk, Duriye; Senyurek, Sukran (Churchill Livingstone, 2024)[Abstract Not Available] -
Global Immune-Nutrition-Inflammation Index as a novel comprehensive biomarker in predicting the radiation-induced trismus rates in locally advanced nasopharyngeal carcinoma patients
Somay, Efsun; Topkan, Erkan; Bascil, Sibel; Durankus, Niluefer Kilic; Senyurek, Sukran; Ozturk, Duriye; Pehlivan, Berrin (Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2024)Nasopharyngeal carcinoma (NPC) is a prevalent cancer in certain regions, often treated with concurrent chemoradiotherapy (CCRT), which can lead to complications such as radiation-induced trismus (RIT). In this study, we ... -
High Systemic Immune-Inflammation Index Values Before Treatment Predict Poor Pancreatic Cancer Outcomes After Definitive Chemoradiotherapy
Topkan, Erkan; Kucuk, Ahmet; Ozturk, Duriye; Ozkan, Emine Elif; Durankus, Niluefer Kilic; Senyurek, Sukran; Selek, Ugur (Sage Publications Ltd, 2024)Background: The systemic immune-inflammation index (SII) is an effective tool for predicting the prognosis of patients with cancer. However, its value in patients with locally advanced pancreatic ductal adenocarcinoma ... -
Novel Somay's GLUCAR Index Efficiently Predicts Survival Outcomes in Locally Advanced Pancreas Cancer Patients Receiving Definitive Chemoradiotherapy: A Propensity-Score-Matched Cohort Analysis
Topkan, Erkan; Senyurek, Sukran; Durankus, Nulifer Kilic; Ozturk, Duriye; Selek, Ugur (Mdpi, 2024)Background: Propensity score matching (PSM) was used to investigate the prognostic value of a novel GLUCAR index [Glucose x (C-reactive protein divided by albumin)] in unresectable locally advanced pancreatic cancer (LA-NPC) ... -
Predicting osteoradionecrosis risk in patients with locoregionally advanced nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy: The value of the CARWL index
Durankus, Nulifer Kilic; Somay, Efsun; Bascil, Sibel; Senyurek, Sukran; Ozturk, Duriye; Selek, Ugur; Topkan, Erkan (Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2024)Osteoradionecrosis (ORN) is a severe complication that can arise in patients with nasopharyngeal carcinoma due to the aggressive nature of chemoradiotherapy treatment. The purpose of our study was to assess the utility of ... -
Radiation-Induced Trismus Triggers Jaw Osteoradionecrosis Development in Locally Advanced Nasopharyngeal Cancer Patients Undergoing Concurrent Chemoradiotherapy
Somay, Efsun; Topkan, Erkan; Ozturk, Duriye; Durankus, Nilufer Kilic; Senyurek, Sukran; Bascil, Sibel; Yenen, Zeynep (Springer India, 2025)To investigate whether radiation-induced trismus (RIT) influences the rates of osteoradionecrosis of the jaw (ORNJ) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) who are undergoing definitive concurrent ... -
The global immune-nutrition-inflammation index (GINI) as a robust prognostic factor in glioblastoma patients treated with the standard stupp protocol
Topkan, Erkan; Durankus, Nilufer Kilic; Senyurek, Sukran; Ozturk, Duriye; Besen, Ali Ayberk; Mertsoylu, Huseyin; Pehlivan, Berrin (Sage Publications Inc, 2024)Background Systemic inflammation can significantly impact gliomas' onset, progression, and prognosis. Glioblastoma multiforme (GBM) represents the glioma subtype characterized by the most profound inflammatory and ... -
The unique CARWL score stratifies locally advanced nasopharyngeal cancer patients receiving concurrent chemoradiotherapy into risk groups for radiation-induced trismus
Senyurek, Sukran; Somay, Efsun; Durankus, Nilufer Kilic; Bascil, Sibel; Ozturk, Duriye; Selek, Ugur; Topkan, Erkan (Springer, 2024)Purpose To determine the utility of the novel CARWL score, which integrates C-reactive protein-to-albumin ratio (CAR) and significant weight loss (SWL), in stratifying the locally advanced nasopharyngeal carcinoma (LA-NPC) ... -
Topkan's CARWL Index Efficiently Predicts the Radiation-Induced Tooth Loss Rates in Radically Treated Locally Advanced Nasopharyngeal Cancer Patients
Somay, Efsun; Topkan, Erkan; Bascil, Sibel; Ozturk, Duriye; Senyurek, Sukran; Durankus, Nilufer Kilic; Selek, Ugur (Sage Publications Inc, 2024)Purpose To assess the usefulness of the novel CARWL index in predicting radiation-induced tooth loss (RITL) rates in locally advanced nasopharyngeal cancer (LA-NPC) patients undergoing concurrent chemoradiotherapy (C-CRT). ...















