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Structure-based design, synthesis, and biological activity evaluation of chalcone-piperazine derivatives as dual AChE and MAO B inhibitors

Kurban, Berkant; Saglik Ozkan, Begum Nurpelin; Osmaniye, Derya; Levent, Serkan; Ozkay, Yusuf; Kaplancikli, Zafer Asim (Royal Soc Chemistry, 2025)

The development of pharmaceutical compounds for the treatment of Alzheimer's Disease (AD) and other neurodegenerative diseases is crucial, as the pathophysiology of AD remains incompletely understood and effective treatments ...