Yazar "Oncu, Seyma" için listeleme
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Anti-Cataract Effect of the Traditional Aqueous Extract of Yerba Mate (Ilex paraguariensis A. St.-Hil.): An In Ovo Perspective
Oncu, Seyma; Becit-Kizilkaya, Merve; Bilir, Abdulkadir; Saritas, Alperen; Arikan-Soylemez, Evrim Suna; Koca, Halit Bugra; Firat, Fatma (Mdpi, 2024)Introduction: The therapeutic effect of different doses of the traditional aqueous extract of dried leaves of yerba mate (Ilex paraguariensis A. St.-Hil.) was investigated in an experimental cataract model in chicken ... -
Berberine enhances the therapeutic effect of 5-fluorouracil in Caco-2 colorectal adenocarcinoma cells by alleviating inflammation and inducing apoptosis
Oncu, Seyma; Becit-Kizilkaya, Merve; Sen, Serkan; Solmaz, Fatma Ozlem Kargin; Celik, Sefa (Cukurova Univ, Fac Medicine, 2023)Purpose: This study aims to investigate whether berberine (BBR) and 5-fluorouracil (5FU), which forms the backbone of chemotherapy, have a synergistic effect on colorectal adenocarcinoma cells (Caco-2) and what mechanisms ... -
Chronic Lymphocytic Leukemia: Investigation of Survival and Prognostic Factors with Drug-Related Remission
Pektas, Gokhan; Gonul, Ercan; Oncu, Seyma; Kizilkaya, Merve Becit; Sadi, Goekhan; Pektas, Mehmet Bilgehan (Mdpi, 2025)Background/Objectives: Understanding the pathogenesis of chronic lymphocytic leukemia (CLL) has led to the development of new prognostic and diagnostic tools, and efforts are underway to extend survival with new prognostic ... -
Daidzein nanosuspension combined with 5-fluorouracil induces apoptosis and alleviate inflammation in Caco-2 colorectal adenocarcinoma cells
Becit-Kizilkaya, Merve; Oncu, Seyma; Sen, Serkan; Kaplan, Afife Busra Ugur; Celik, Sefa; Cetin, Meltem; Dilsiz, Sevtap Aydin (Elsevier, 2024)Colorectal cancer is the third most common malignancy worldwide and the second most common cause of cancer deaths. Alternative treatment strategies, including nano-based formulations, show remarkable promise to improve the ... -
Daidzein nanosuspension in combination with cisplatin to enhance therapeutic efficacy against A549 non-small lung cancer cells: an in vitro evaluation
Oncu, Seyma; Becit-Kizilkaya, Merve; Sen, Serkan; Ugur-Kaplan, Afife Busra; Cetin, Meltem; Celik, Sefa (Springer, 2024)Lung cancer is the most common cause of cancer-related mortality, chemo-resistance, and toxicity limit treatment. The focus is on innovative combined phytotherapy to improve treatment outcomes. Our aim was to investigate ... -
Effect of post-gastrulation exposure to acrylamide on chick embryonic development
Becit-Kizilkaya, Merve; Oncu, Seyma; Bilir, Abdulkadir; Atay, Emre; Soylemez, Evrim Suna Arikan; Firat, Fatma; Aladag, Tugce (Academic Press Inc Elsevier Science, 2024)The critical developmental stages of the embryo are strongly influenced by the dietary composition of the mother. Acrylamide is a food contaminant that can form in carbohydrate-rich foods that are heat-treated. The aim of ... -
Effect of Stevia rebaudiana Bertoni aqueous extract on steroid-induced cataract in chick embryo model
Becit-Kizilkaya, Merve; Oncu, Seyma; Bilir, Abdulkadir; Koca, Halit Bugra; Firat, Fatma; Soylemez, Evrim Suna Arikan; Kurt, Gulan Albas (Elsevier, 2024)Stevia has been used for years as a traditional remedy and sweetener, but its effect on the eye has not been adequately studied. In this study, we aimed to investigate the effect of Stevia rebaudiana Bertoni aqueous extract ... -
Evaluation of anti-seizure medications and their serum concentration with regard to cardiovascular risk parameters: A cross-sectional study
Becit-Kizilkaya, Merve; Oncu, Seyma; Koca, Halit Bugra; Cavusoglu, Dilek (Academic Press Inc Elsevier Science, 2024)Objective: Epilepsy is a chronic disease that requires long-term monitoring and treatment. It is suspected that there is a interaction between the use of anti-seizure medications and the risk of cardiovascular disease. The ... -
EVALUATION OF SERUM DRUG CONCENTRATIONS IN A TERTIARY CARE HOSPITAL: A CROSS-SECTIONAL STUDY
Becit-Kizilkaya, Merve; Oncu, Seyma; Cavusoglu, Dilek; Koca, Halit Bugra (Dokuz Eylul Univ Inst Health Sciences, 2024)Background: Serum drug concentration (SDC) is an important parameter used in drug efficacy and treatment follow-up. Aim: This study aimed to evaluate subtherapeutic, therapeutic and toxic SDCs, SDC measurement requests and ... -
Evaluation of the relationship of treatment and vaccination with prognosis in patients with a diagnosis of COVID-19
Oncu, Seyma; Korkmaz, Derya (Springer Basel Ag, 2024)Purpose Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide and caused mortality. Many factors have been reported to affect the prognosis of COVID-19. In this study, we aimed to investigate the ... -
Evaluation of therapeutic and toxic levels of serum digoxin concentration: a cross-sectional study from a tertiary hospital
Koca, Halit Bu?ra; Oncu, Seyma; Becit, Merve; Gökaslan, Serkan (Verduci Editore s.r.l, 2024)OBJECTIVE: Digoxin is a cardiac glycoside for treating heart failure and atrial fibrillation. Despite its limited therapeutic range and complex pharmacokinetic properties, this medication continues to be frequently prescribed. ... -
Retrospective Evaluation of Survival and Prognostic Factors in Immune Thrombocytopenia: A Single-Center and Cross-Sectional Study
Pektas, Gokhan; Uncu, Ibrahim Asaf; Dere, Yelda; Oncu, Seyma; Kizilkaya, Merve Becit; Sadi, Gokhan; Pektas, Mehmet Bilgehan (Mdpi, 2024)Background and Objectives: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by the autoantibody-mediated destruction of platelets. The treatment of ITP aims to maintain a sufficient platelet count to ... -
THE KNOWLEDGE, OPINIONS, ATTITUDES OF PHYSICIANS ABOUT BIOSIMILAR DRUGS: A UNIVERSITY HOSPITAL DATA
Gokdemir, Ebru; Oncu, Seyma; Gelal, Ayse; Ucku, Reyhan; Arici, Mualla Aylin (Dokuz Eylul Univ Inst Health Sciences, 2022)Purpose: To evaluate the knowledge, opinions and prescribing attitudes of physicians working in an university hospital about biosimilar drugs and analyse the factors affect these parameters. Methods: In this descriptive, ...
