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Anti-Cataract Effect of the Traditional Aqueous Extract of Yerba Mate (Ilex paraguariensis A. St.-Hil.): An In Ovo Perspective
Oncu, Seyma; Becit-Kizilkaya, Merve; Bilir, Abdulkadir; Saritas, Alperen; Arikan-Soylemez, Evrim Suna; Koca, Halit Bugra; Firat, Fatma (Mdpi, 2024)Introduction: The therapeutic effect of different doses of the traditional aqueous extract of dried leaves of yerba mate (Ilex paraguariensis A. St.-Hil.) was investigated in an experimental cataract model in chicken ... -
Berberine enhances the therapeutic effect of 5-fluorouracil in Caco-2 colorectal adenocarcinoma cells by alleviating inflammation and inducing apoptosis
Oncu, Seyma; Becit-Kizilkaya, Merve; Sen, Serkan; Solmaz, Fatma Ozlem Kargin; Celik, Sefa (Cukurova Univ, Fac Medicine, 2023)Purpose: This study aims to investigate whether berberine (BBR) and 5-fluorouracil (5FU), which forms the backbone of chemotherapy, have a synergistic effect on colorectal adenocarcinoma cells (Caco-2) and what mechanisms ... -
Comparative analysis of chemical composition and biological activities of Punica granatum L. Extracts: UPLC-MS/MS profiling, antioxidant capacity, enzyme inhibition, and molecular docking
Duysak, Lale; Erturk, Adem; Becit-Kizilkaya, Merve; Aksoy, Betul; Gulcin, Ilhami (Elsevier, 2025)Pomegranate (Punica granatum L.) has been valued for its medicinal and nutritional benefits across traditional healing systems. This study investigated the phytochemical profile, antioxidant capacity, and enzyme inhibitory ... -
Comprehensive UPLC-MS/MS-based metabolic profiling, antioxidant potential, enzyme inhibition, and molecular docking studies of Ficus carica L. leaves: Potential for functional food applications
Duysak, Lale; Erturk, Adem; Becit-Kizilkaya, Merve; Gulcin, Ilhami (Elsevier, 2025)Fig (Ficus carica L.) is a fruit tree consumed worldwide as a functional food. While its fruit is well-studied, the phytochemicals and biological activities of its leaves have not been reported in detail. This study ... -
Daidzein nanosuspension combined with 5-fluorouracil induces apoptosis and alleviate inflammation in Caco-2 colorectal adenocarcinoma cells
Becit-Kizilkaya, Merve; Oncu, Seyma; Sen, Serkan; Kaplan, Afife Busra Ugur; Celik, Sefa; Cetin, Meltem; Dilsiz, Sevtap Aydin (Elsevier, 2024)Colorectal cancer is the third most common malignancy worldwide and the second most common cause of cancer deaths. Alternative treatment strategies, including nano-based formulations, show remarkable promise to improve the ... -
Daidzein nanosuspension in combination with cisplatin to enhance therapeutic efficacy against A549 non-small lung cancer cells: an in vitro evaluation
Oncu, Seyma; Becit-Kizilkaya, Merve; Sen, Serkan; Ugur-Kaplan, Afife Busra; Cetin, Meltem; Celik, Sefa (Springer, 2024)Lung cancer is the most common cause of cancer-related mortality, chemo-resistance, and toxicity limit treatment. The focus is on innovative combined phytotherapy to improve treatment outcomes. Our aim was to investigate ... -
Effect of post-gastrulation exposure to acrylamide on chick embryonic development
Becit-Kizilkaya, Merve; Oncu, Seyma; Bilir, Abdulkadir; Atay, Emre; Soylemez, Evrim Suna Arikan; Firat, Fatma; Aladag, Tugce (Academic Press Inc Elsevier Science, 2024)The critical developmental stages of the embryo are strongly influenced by the dietary composition of the mother. Acrylamide is a food contaminant that can form in carbohydrate-rich foods that are heat-treated. The aim of ... -
Effect of Stevia rebaudiana Bertoni aqueous extract on steroid-induced cataract in chick embryo model
Becit-Kizilkaya, Merve; Oncu, Seyma; Bilir, Abdulkadir; Koca, Halit Bugra; Firat, Fatma; Soylemez, Evrim Suna Arikan; Kurt, Gulan Albas (Elsevier, 2024)Stevia has been used for years as a traditional remedy and sweetener, but its effect on the eye has not been adequately studied. In this study, we aimed to investigate the effect of Stevia rebaudiana Bertoni aqueous extract ... -
Evaluation of anti-seizure medications and their serum concentration with regard to cardiovascular risk parameters: A cross-sectional study
Becit-Kizilkaya, Merve; Oncu, Seyma; Koca, Halit Bugra; Cavusoglu, Dilek (Academic Press Inc Elsevier Science, 2024)Objective: Epilepsy is a chronic disease that requires long-term monitoring and treatment. It is suspected that there is a interaction between the use of anti-seizure medications and the risk of cardiovascular disease. The ... -
EVALUATION OF SERUM DRUG CONCENTRATIONS IN A TERTIARY CARE HOSPITAL: A CROSS-SECTIONAL STUDY
Becit-Kizilkaya, Merve; Oncu, Seyma; Cavusoglu, Dilek; Koca, Halit Bugra (Dokuz Eylul Univ Inst Health Sciences, 2024)Background: Serum drug concentration (SDC) is an important parameter used in drug efficacy and treatment follow-up. Aim: This study aimed to evaluate subtherapeutic, therapeutic and toxic SDCs, SDC measurement requests and ...
