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Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region-associated protein synthesis and TLR4/NF-κB signaling pathway

Yılmaz, Seher; Doğanyiğit, Züleyha; Oflamaz, Aslı Okan; Ateş, Şükrü; Uçar, Sümeyye; Arıkan Söylemez, Evrim Suna (Wiley-Blackwell, 2022)

In this study, the protective effect of melatonin was investigated in lipopolysaccharide induced sepsis model. Twenty-eight rats were randomly divided: Control, Melatonin, LPS and LPS + Melatonin. After LPS application, ...
Determination of Rutin's antitumoral effect on EAC solid tumor by AgNOR count and PI3K/AKT/mTOR signaling pathway

Yılmaz, Seher; Doğanyiğit, Züleyha; Oflamaz, Aslı Okan; Ateş, Şükrü; Arıkan Söylemez, Evrim Suna; Nisari, Mehtap; Farooqi, Ammad Ahmed (Springer, 2023)

Rutin is one of the flavonoids found in fruits and vegetables. The PI3K/AKT/mTOR signaling pathway is critical for the life cycle at the cellular level. In current study, we purposed to demonstrate the antitumoral effect ...