Intraosseous infusion of diazepam using spinal needle

Abstract

Seizure can cause serious brain damage if it prolongs. it is general need to terminale seizure as soon as possible using anticonvulsant drugs via intravenous (IV) route. But, it is very difficult to achieve secure IV line during the seizure. On the other hand, intraosseous (IO) access is available. in this study, diazepam was administered to rabbits using both IV and IO lines at the döşe of 0.2 mg/kg. Blood samples were collected from ear vein for time period of 20 minutes and analyzed. Blood plâsma diazepam concentrations were determined and their profiles were compared. The IO line appeared to be an alternative route to IV access in the administration of diazepam.