Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey

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dc.contributor.authorSarıkürkçü, Cengiz
dc.contributor.authorÖzer, Mehmet Sabih
dc.contributor.authorİstifli, Erman Salih
dc.contributor.authorŞahinler, Saliha Şeyma
dc.contributor.authorTepe, Bektaş
dc.date.accessioned2021-05-05T22:11:50Z
dc.date.available2021-05-05T22:11:50Z
dc.date.issued2021
dc.departmentAFSÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü
dc.description2-s2.0-85103331629en_US
dc.description.abstractSideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant and enzyme inhibitory activities of solvent extracts of S. leptoclada O. Schwarz & P.H. Davis, an endemic species. It was determined that methanol (MeOH) and water extracts contained high amounts of chlorogenic acid and verbascoside, while the ethyl acetate (EtOAc) extract contained high amounts of 4-hydroxybenzoic and vanilic acids. The water extract showed the highest antioxidant activity in almost all parameters. Inhibitory activity of the MeOH extract on tyrosinase was 1.04 mg/ml, which was the highest value in this experiment. On the other hand, in ?-amylase inhibitory assay, the EtOAc extract showed an activity of 2.21 mg/ml. Docking analysis showed that verbascoside can be an effective tyrosinase and ?-amylase inhibitory agent. © 2021 SAABen_US
dc.identifier.doi10.1016/j.sajb.2021.03.020
dc.identifier.issn0254-6299
dc.identifier.scopus2-s2.0-85103331629
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2021.03.020
dc.identifier.urihttps://hdl.handle.net/20.500.12933/160
dc.identifier.wosWOS:000767313800015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSarıkürkçü, Cengiz
dc.language.isoen
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectPhytochemical compositionen_US
dc.subjectSideritis leptocladaen_US
dc.subjectTyrosinase inhibitoryen_US
dc.subject?-Amylase inhibitoryen_US
dc.titleChromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkeyen_US
dc.typeArticle

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