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dc.contributor.authorKırkan, Bülent
dc.contributor.authorOlcay, Ceylan
dc.contributor.authorSarıkürkçü, Cengiz
dc.contributor.authorTepe, Bektaş
dc.date.accessioned2022-06-14T13:09:12Z
dc.date.available2022-06-14T13:09:12Z
dc.date.issued2021en_US
dc.identifier.citationKirkan, B., Ceylan, O., SARIKÜRKCÜ, C., & Bektas, T. E. P. E. (2021). Phenolic profile, antioxidant and enzyme inhibitory activity of the ethyl acetate, methanol and water extracts of Capparis spinosa L. International Journal of Secondary Metabolite, 8(4), 337-351.en_US
dc.identifier.issn2148-6905
dc.identifier.urihttps://doi.org/10.21448/ijsm.981149
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1164
dc.description.abstractIn this study, it was aimed to determine the phytochemical compositions and biological activities of ethyl acetate (EtOAc), methanol (MeOH) and water extracts obtained from the aerial parts of Capparis spinosa L. As a result of spectrophotometric analyzes, MeOH extract was found to be richer in terms of both phenolics and flavonoids compared to other extracts [81.45 mg GAEs (gallic acid equivalent)/g and 36.57 mg RE (rutin equivalent)s/g, respectively], while chromatographic analyzes showed that the extract in question contains a significant amount of hepseridin (72927.48 µg/g), quercetin (1335.88 µg/g), hyperoside (1227.73 µg/g), and 4-hydroxybenzoic acid (924.08 µg/g). Phosphomolybdenum, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging, Cupric Reducing Antioxidant Power (CUPRAC) and Ferric Reducing Antioxidant Power (FRAP) reducing and ferrous ion chelating activity tests resulted in superiority of MeOH extract [371.0, 44.93, 56.46, 91.77, 52.61 mg TEs (trolox equivalent)/g and 14.85 mg EDTAEs/g, respectively]. On the other hand, EtOAc extract exhibited higher activity than other extracts in acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-amylase, and α-glucosidase inhibitory activity tests [3.29, 2.12 mg GALAEs (galanthamine equivalent)/g, 541.01 and 1584.20 mg ACEs (acarbose equivalent)/g, respectively]. The tyrosinase inhibitory activity test resulted in the superiority of MeOH extract [41.90 mg KAEs (kojic acid equivalent)/g]. A strong correlation was determined between the phenolic and flavonoid contents of the extracts and their antioxidant activities.en_US
dc.language.isoengen_US
dc.publisherPamukkale Universityen_US
dc.relation.isversionof10.21448/ijsm.981149en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCapparis spinosaen_US
dc.subjectLC–ESI–MS/MSen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitoryen_US
dc.subjectChemical compositionen_US
dc.titlePhenolic profile, antioxidant and enzyme inhibitory activity of the ethyl acetate, methanol and water extracts of Capparis spinosa L.en_US
dc.typearticleen_US
dc.authorid0000-0001-5094-2520en_US
dc.departmentAFSÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.contributor.institutionauthorSarıkürkçü, Cengiz
dc.identifier.volume8en_US
dc.identifier.issue4en_US
dc.identifier.startpage337en_US
dc.identifier.endpage351en_US
dc.relation.journalInternational Journal of Secondary Metaboliteen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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