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dc.contributor.authorDüzenli Kar, Yeter
dc.contributor.authorÖzdemir, Zeynep Canan
dc.contributor.authorBör, Özcan
dc.date.accessioned2022-06-14T12:38:49Z
dc.date.available2022-06-14T12:38:49Z
dc.date.issued2021en_US
dc.identifier.citationDüzenli Kar, Y., Özdemir, Z. C., & Bör, Ö. (2021). Thiol/disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpura.en_US
dc.identifier.issn0041-4301
dc.identifier.urihttps://doi.org/10.24953/turkjped.2021.06.003
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1163
dc.description.abstractBackground. Changes in oxidative stress and thiol / disulfide balance are thought to play a role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP). Our study investigates total oxidant level (TOS), total antioxidant level (TAS), oxidative stress index (OSI) levels and thiol / disulfide balance in pediatric patients with acute and chronic ITP. Methods. Thirty four patients with acute ITP, eighteen patients with chronic ITP and thirty three healthy children (control) were included. TOS, TAS, OSI, thiol / disulfide balance were analyzed. Results. In acute ITP, TAS levels were lower than chronic ITP and control, TOS and OSI levels were higher than control, and native thiol level was lower than chronic ITP (p <0.05). In acute ITP; disulfide level, disulfide / native thiol and disulfide / total thiol ratios were higher than chronic ITP and control, and native thiol / total thiol ratio was lower than chronic ITP and control group (p = 0.038, p = 0.018, respectively). TOS and OSI levels of the chronic ITP were higher than the control group (p <0.05). Conclusions. The results of this study have shown that oxidative stress increases in children with acute ITP and chronic ITP, that thiol / disulfide balance is disrupted in favor of disulfide in acute ITP, and that thiol / disulfide balance isn`t disrupted in chronic ITP patients whose platelet count is close to normal and who don`t require treatment.en_US
dc.language.isoengen_US
dc.publisherTurkish National Pediatric Societyen_US
dc.relation.isversionof10.24953/turkjped.2021.06.003en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcuteen_US
dc.subjectChronicen_US
dc.subjectITPen_US
dc.subjectOxidative stressen_US
dc.subjectTASen_US
dc.subjectThiol / disulfide balanceen_US
dc.subjectTOSen_US
dc.titleThiol / disulfide balance and oxidative stress parameters in pediatric patients diagnosed with acute and chronic idiopathic thrombocytopenic purpuraen_US
dc.typearticleen_US
dc.authorid0000-0003-2917-7750en_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorDüzenli Kar, Yeter
dc.identifier.volume63en_US
dc.identifier.issue6en_US
dc.identifier.startpage962en_US
dc.identifier.endpage969en_US
dc.relation.journalTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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