Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorEroğul, Özgür
dc.contributor.authorBeysel, Selvihan
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorGobeka, Hamidu Hamisi
dc.contributor.authorKaşıkcı, Murat
dc.contributor.authorEryiğit Eroğul, Leyla
dc.date.accessioned2022-05-09T10:47:19Z
dc.date.available2022-05-09T10:47:19Z
dc.date.issued2021en_US
dc.identifier.citationEroğul, Ö. , Beysel, S. , Doğan, M. , Gobeka, H. H. , Kaşıkcı, M. & Eryiğit Eroğul, L. (2021). Biochemical analysis of serum mineral and vitamin levels in benign essential blepharospasm . Journal of Surgery and Medicine , 5 (5) , 495-499 . DOI: 10.28982/josam.924395en_US
dc.identifier.issn2602-2079
dc.identifier.urihttps://doi.org/10.28982/josam.924395
dc.identifier.urihttps://hdl.handle.net/20.500.12933/953
dc.description.abstractBackground/Aim: Benign essential blepharospasm (BEB) is a type of focal dystonia characterized by involuntary periocular muscle spasms, resulting in partial or complete eyelid closure. Though BEB has been linked to a variety of mineral and vitamin D deficiencies, its association with serum vitamin B12 has never been studied. We intended to determine the association between vitamin B12, serum calcium, magnesium, phosphorus, and 25-(OH) vitamin D levels, and BEB severity and frequency. Methods: This retrospective case-control study included 20 BEB patients who were followed-up and treated periodically with botulinum toxin injections in Afyonkarahisar Health Sciences University Department of Ophthalmology’s Oculoplastic and Reconstructive Surgery Unit between January 2019 and January 2021. Twenty age- and gender-matched healthy individuals were also included. The Jankovic rating scale was used to determine the severity and frequency of BEB. Acquired data were assessed retrospectively in terms of age, gender, serum minerals, 25 (OH)-Vitamin D and Vitamin B12 levels. Results: In this study, 20 BEB patients (F:M=14:6) and 20 healthy individuals (F:M=12:8) (P=0.321) were investigated. The mean ages of BEB patients and healthy individuals were 64.37 (4.21) and 63.83 (3.13) years, respectively (P=0.239). Compared to healthy individuals, BEB patients had significantly lower serum levels of 25-(OH) vitamin D (P=0.037), vitamin B12 (P=0.014) and calcium (P=0.011). In BEB patients, serum levels of 25-(OH) vitamin D (r=-0.375, P=0.043), calcium (r=-0.319, P=0.039), and vitamin B12 (r=-0.408, P=0.027) were all strongly negatively correlated with the Jankovic severity score. Conclusion: A strong negative correlation between disease severity and decreased vitamin B12, 25-(OH) vitamin D, and calcium in BEB patients indicated that, among other things, BEB may be a rare form of vitamin B12 deficiency. In the absence of an obvious cause for BEB, serum vitamin B12 testing, in addition to serum minerals and 25-(OH) vitamin D, may be useful.en_US
dc.language.isoengen_US
dc.publisherFatih BAŞAKen_US
dc.relation.isversionof10.28982/josam.924395en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBenign essential blepharospasmen_US
dc.subjectVitamin B12en_US
dc.subjectMagnesiumen_US
dc.subjectPhosphorus, Calciumen_US
dc.subject25-(OH) vitamin D,en_US
dc.subjectJankovic rating scaleen_US
dc.titleBiochemical analysis of serum mineral and vitamin levels in benign essential blepharospasmen_US
dc.typearticleen_US
dc.authorid0000-0002-0875-1517en_US
dc.authorid0000-0001-6963-1503en_US
dc.authorid0000-0001-7237-9847en_US
dc.authorid0000-0002-7656-3155en_US
dc.authorid0000-0002-2748-9702en_US
dc.authorid0000-0003-3622-2089en_US
dc.departmentAFSÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorEroğul, Özgür
dc.contributor.institutionauthorBeysel, Selvihan
dc.contributor.institutionauthorDoğan, Mustafa
dc.identifier.volume5en_US
dc.identifier.issue5en_US
dc.identifier.startpage495en_US
dc.identifier.endpage499en_US
dc.relation.journalJournal of Surgery and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster