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dc.contributor.authorEkici, Ömer
dc.contributor.authorAslan, Esra
dc.contributor.authorGüzel, Hilal
dc.contributor.authorKorkmaz, Ömer Adil
dc.contributor.authorSadi, Gökhan
dc.contributor.authorGürol, Ahmet Muhtar
dc.contributor.authorBoyacı, Mehmet Gazi
dc.contributor.authorPektaş, Mehmet Bilgehan
dc.date.accessioned2022-04-29T11:01:14Z
dc.date.available2022-04-29T11:01:14Z
dc.date.issued06.10.2021en_US
dc.identifier.citationEkici, O., Aslan, E., Guzel, H., Korkmaz, O. A., Sadi, G., Gurol, A. M., ... & Pektas, M. B. (2022). Kefir alters craniomandibular bone development in rats fed excess dose of high fructose corn syrup. Journal of Bone and Mineral Metabolism, 40(1), 56-65.en_US
dc.identifier.issn0914-8779
dc.identifier.issn1435-5604
dc.identifier.urihttps://doi.org/10.1007/s00774-021-01273-8
dc.identifier.urihttps://hdl.handle.net/20.500.12933/876
dc.description.abstractIntroduction: Dietary high fructose corn syrup (HFCS) is involved in the pathogenesis of oral diseases as well as metabolic diseases. The aim of this study was to investigate the effects of HFCS-feeding on the craniomandibular bone development at an early age and also the potential of milk kefir for preventive treatment. Materials and methods: In this study, Control, Kefir, HFCS, and HFCS plus Kefir groups were formed; kefir was given by gastric gavage, while HFCS (20% beverages) was given in drinking water; for 8 weeks. Results: Based on morphological evaluations, immunohistochemical, and gene expression results, it was clearly determined that excess dose of HFCS consumption decreased osteoblastic activity in craniomandibular bones while increasing osteoclastic activity. However, it has been determined that the intake of kefir with the HFCS-feeding greatly suppresses the effects of HFCS on bone tissues. Conclusion: In conclusion, dietary the excess dose of HFCS at an early age has been observed to pose a risk for cranial and mandible bone development. The healing effects of kefir may be a new approach to the treatment via kefir consumption in young's.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s00774-021-01273-8en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectHFCSen_US
dc.subjectKefiren_US
dc.subjectCraniomandibular boneen_US
dc.subjectRANKLen_US
dc.subjectRUNX2en_US
dc.titleKefir alters craniomandibular bone development in rats fed excess dose of high fructose corn syrupen_US
dc.typearticleen_US
dc.authorid0000-0002-7902-9601en_US
dc.authorid0000-0002-3191-4978en_US
dc.authorid0000-0001-7692-8890en_US
dc.authorid0000-0001-5670-1314en_US
dc.authorid0000-0002-6422-1203en_US
dc.authorid0000-0002-0383-2326en_US
dc.authorid0000-0001-7329-2102en_US
dc.authorid0000-0003-0055-7688en_US
dc.departmentAFSÜ, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümüen_US
dc.contributor.institutionauthorEkici, Ömer
dc.contributor.institutionauthorAslan, Esra
dc.contributor.institutionauthorGüzel, Hilal
dc.contributor.institutionauthorGürol, Ahmet Muhtar
dc.contributor.institutionauthorBoyacı, Mehmet Gazi
dc.contributor.institutionauthorPektaş, Mehmet Bilgehan
dc.identifier.volume40en_US
dc.identifier.issue1en_US
dc.identifier.startpage56en_US
dc.identifier.endpage65en_US
dc.relation.journalJournal of Bone and Mineral Metabolismen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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