Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorKoca Yozgat, Ayça
dc.contributor.authorEker, İbrahim
dc.contributor.authorGürsel, Orhan
dc.contributor.authorKılınçkaya, Muhammed Fevzi
dc.contributor.authorKara, Abdurrahman
dc.contributor.authorYaralı, Neşe
dc.contributor.authorÖzbek, Namık Yaşar
dc.date.accessioned2022-04-27T06:48:15Z
dc.date.available2022-04-27T06:48:15Z
dc.date.issued2021en_US
dc.identifier.citationYozgat, A. K., Eker, İ., Gürsel, O., Kılınçkaya, M. F., Kara, A., Yaralı, N., & Özbek, N. Y. (2021). Thrombin generation in children with febrile neutropenia. The Turkish Journal of Pediatrics, 63(2), 251-256.en_US
dc.identifier.issn0041-4301
dc.identifier.issn2791-6421
dc.identifier.urihttps://doi.org/10.24953/turkjped.2021.02.008
dc.identifier.urihttps://hdl.handle.net/20.500.12933/840
dc.description.abstractBackground. Febrile neutropenia (FN) is a common and serious complication in patients with leukemia. Hemostasis and inflammation are two interrelated systems in response to infection. We aimed to investigate the course of thrombin formation in febrile neutropenia attack of children with acute lymphoblastic leukemia (ALL). Methods. Thrombin generation was monitored in children treated for ALL at diagnosis of febrile neutropenia (FN) (t0), at 48th hour of FN (t1) and after recovery from neutropenia (t2). Results. Twenty-nine patients and 50 healthy children as control were enrolled into the study. Mean endogenous thrombin potential (ETP) and mean peak value of thrombin results at t1 were significantly higher than at t0, t2 and control groups, respectively. A positive but statistically nonsignificant correlation between ETP values at t1 and duration of neutropenia was observed. Conclusion. Although thrombin generation is enhanced both due to chemotherapy or malignancy itself, our results revealed that thrombin formation also increased in neutropenic infection of children with leukemia.en_US
dc.language.isoengen_US
dc.publisherAnkara : Hacettepe Medical Centeren_US
dc.relation.isversionof10.24953/turkjped.2021.02.008en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute lymphoblastic leukemiaen_US
dc.subjectFebrile neutropeniaen_US
dc.subjectThrombin generationen_US
dc.titleThrombin generation in children with febrile neutropeniaen_US
dc.typearticleen_US
dc.authorid0000-0001-6690-721Xen_US
dc.authorid0000-0002-1880-546Xen_US
dc.authorid0000-0002-2077-8093en_US
dc.authorid0000-0002-0815-5467en_US
dc.authorid0000-0001-6156-3219en_US
dc.authorid0000-0001-5488-2385en_US
dc.authorid0000-0001-6857-0681en_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorEker, İbrahim
dc.identifier.volume63en_US
dc.identifier.issue2en_US
dc.identifier.startpage251en_US
dc.identifier.endpage256en_US
dc.relation.journalThe Turkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster