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dc.contributor.authorKartal, Ömer
dc.contributor.authorGürsel, Orhan
dc.contributor.authorEker, İbrahim
dc.contributor.authorTaşçılar, Mehmet Emre
dc.contributor.authorTapan, Serkan
dc.contributor.authorKürekçi, Ahmet Emin
dc.date.accessioned2021-05-05T22:16:58Z
dc.date.available2021-05-05T22:16:58Z
dc.date.issued2020
dc.identifier.issn2602-3164
dc.identifier.issn2602-3164
dc.identifier.urihttps://doi.org/10.14744/ejmi.2020.15888
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpZME16a3hNUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12933/515
dc.description.abstractObjectives: Despite the important improvements in prevention and treatment, febrile neutropenia is still a common challenge in patients with certain hematological disorders. Many biomarkers have been explored to identify high-risk neutropenic patients, which need hospitalization and broad-spectrum antibiotic treatment. In the present study, firstly, we aimed to investigate serum CRP, Chitotriosidase (CtH) and Neutrophil gelatinase-associated lipocalin level (NGAL) in febrile neutropenia, non-febrile neutropenia and control groups. Secondly, to evaluate the usefulness of CRP, CtH and NGAL as a inflammatory biomarker to detect slight inflammatory change associated with infection in these patients. Methods: This was a single center prospective study that investigated ChT and NGAL as a new biomarkers to detect slight inflammatory change associated with infection in febrile neutropenia, non-febrile neutropenia and control groups. Therefore, 168 serum samples, which were obtained from 26 patients with hematological disorders were divided into three groups; Febrile neutropenia, non-febrile neutropenia and control group. Results: The mean serum CRP, CtH and NGAL levels of febrile neutropenia group were significantly higher than the other two groups (p<0.05). However, there was not any statistically significant difference between non-febrile neutropenia and control groups (P>0.05). C-reactive protein had a positive and significant correlation with CtH (r=0.548, p<0. 05) and NGAL (r=0.311, p<0.05). Moreover, there was a positive and significant correlation between CtH and NGAL (r=0.247, p<0. 05). The area under the curve (AUC) values were found as 0.68 (0.48–0.79), 0.72 (0.56–0.87), 0.72 (0.56– 0.87), 0.56 (0.39–0.66) for CRP, CtH and NGAL respectively and there was not any significant difference between any two AUC values (p>0.05). Conclusion: Serum ChT level is the most sensitive and specific biomarker to detect slight inflammatory change associated with infection in febrile neutropenic patients. Therefore, in the future, it may be used instead of or in combination with CRP to discriminate critically ill patients, to prevent unnecessary hospitalization and antibiotic treatment in neutropenia.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChemotherapyen_US
dc.subjectChitotriosidase
dc.subjectC-reactive protein
dc.subjectFebrile neutropenia
dc.subjectNeutrophil gelatinase-associated lipocalin
dc.titleChitotriosidase and Neutrophil Gelatinase-Associated Lipocalin: New Methods as a Diagnostic Marker of Infection in Patients with Febrile Neutropenia?en_US
dc.typearticleen_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorEker, İbrahim
dc.identifier.doi10.14744/ejmi.2020.15888
dc.identifier.volume4en_US
dc.identifier.issue2en_US
dc.identifier.startpage199en_US
dc.identifier.endpage203en_US
dc.relation.journalEurasian Journal of Medical Investigationen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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