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dc.contributor.authorBeypınar, İsmail
dc.contributor.authorDemir, Hacer
dc.contributor.authorAraz, Murat
dc.contributor.authorUysal, Mükremin
dc.date.accessioned2021-05-05T22:16:54Z
dc.date.available2021-05-05T22:16:54Z
dc.date.issued2019
dc.identifier.issn2651-4532
dc.identifier.urihttps://doi.org/10.1016/j.jons.2019.08.002
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpVMU1EYzVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12933/437
dc.description.abstractAim: The metastatic pattern of non-small cell lung cancer (NSCLC) has been described in several studies. Frequent metastatic sites are lung, liver, bone, surrenal, and brain. Hypotheses were speculated to explain the tendency of specific sites. Over-expression of EGFR alters the biology and tumoral behavior. The mutations of EGFR mainly occur in exon 19, and 21and could lead the way through the tumor growth and metastasis. We try to elucidate the relationship between EGFR mutation and metastatic pattern. Material and Method: In this retrospective nested case-control study, one hundred and five patients diagnosed with lung adenocarcinoma included who had EGFR mutation status and imaging studies at the time of diagnosis. Results: The metastatic pattern was not different between EGFR mutant and wild type patients. There was no statistical difference in terms of survival between EGFR mutant and wild type patients (p ¼ 0.25). The OS according to the organ metastasis between EGFR mutant and wild type group was not significant except liver. The EGFR mutant patients with liver metastasis had better survival compared with wild type patients (p ¼ 0.04). Also, the multiplicity and solidarity of the metastatic tumors were compared in metastatic organs. There was no significant difference between groups. The subsequent EGFR mutation type was not related to the metastatic pattern. Conclusion: The incidence of the metastatic sites was not different between EGFR mutant and wild type patients in our study. In contrast to the literature, liver metastasis found to be related to improved OS.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleThe relationship between EGFR mutation and metastasis pattern in lung adenocarcinomaen_US
dc.typearticleen_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorBeypınar, İsmail
dc.contributor.institutionauthorDemir, Hacer
dc.contributor.institutionauthorUysal, Mükremin
dc.identifier.doi10.1016/j.jons.2019.08.002
dc.identifier.volume5en_US
dc.identifier.issue2en_US
dc.identifier.startpage65en_US
dc.identifier.endpage69en_US
dc.relation.journalJournal of oncological sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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