dc.contributor.author | Akdoğan, Müberra | |
dc.contributor.author | Üstündağ, Yasemin | |
dc.contributor.author | Akdağ, Arzu | |
dc.contributor.author | Neşelioğlu, Salim | |
dc.contributor.author | Erel, Özcan | |
dc.date.accessioned | 2021-05-05T22:14:16Z | |
dc.date.available | 2021-05-05T22:14:16Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1874-3641 | |
dc.identifier.uri | https://doi.org/10.2174/1874364101913010023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12933/401 | |
dc.description | WOS:000476645600002 | en_US |
dc.description.abstract | Purpose: This study was performed to determine whether one drop of topical administration of Coqun (R) (Coenzyme Q10 and Vitamin E)-a potent antioxidant-twice a day has any effect on the thiol-disulphide homeostasis-a novel oxidative stress marker in the Retinopathy Of Prematurity (ROP) disease course. Methods: This was a prospective observational study comprising 28 infants with ROP at stage 2 and higher who followed up at the paediatric intensive care unit. Ferric reducing power of plasma (FRAP), albumin, ischemia-modified albumin (IMA) and thiol disulphide homeostasis levels were studied in the infants before and two weeks after Coqun (R) treatment. Results: The mean gestational age was 27 (24-32) weeks, the mean birth weight was 1,012 +/- 326 g and the mean duration of care in an incubator was 64 +/- 23 days. FRAP levels were 0.91 +/- 0.17 mu mol/L, IMAs were 0.85 +/- 0.29, native thiols were 248 +/- 38.9 mu mol/L and total thiols were 284 +/- 39.2 mu mol/L, respectively, at the beginning of therapy. FRAP levels 0.79 +/- 0.21(p=0.006) mu mol/L, IMAs 0.73 +/- 0.36(p = 0.096), native thiols 262 +/- 42.6(p = 0.164) mu mol/L and total thiols 291 +/- 43.6(p = 0.344) mu mol/L showed no difference after two weeks of therapy. Conclusion: Thiol disulphide homeostasis levels do not change with Coqun (R) therapy during ROP course. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Bentham Science Publ Ltd | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Coenzyme Q10 | en_US |
dc.subject | Retinopathy of Prematurity | en_US |
dc.subject | Thiol | en_US |
dc.subject | Vitamin E | en_US |
dc.subject | FRAP | en_US |
dc.title | The Thiol-Disulfide Homeostasis and Coenzyme Q10 in Conjunction with Vitamin E Effect on Retinopathy Prematurity | en_US |
dc.type | article | en_US |
dc.department | AFSÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı | en_US |
dc.contributor.institutionauthor | Akdoğan, Müberra | |
dc.identifier.doi | 10.2174/1874364101913010023 | |
dc.identifier.volume | 13 | en_US |
dc.identifier.startpage | 23 | en_US |
dc.identifier.endpage | 28 | en_US |
dc.relation.journal | Open Ophthalmology Journal | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |