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dc.contributor.authorKorkmaz, Ömer Adil
dc.contributor.authorŞumlu, Esra
dc.contributor.authorKoca, Halit Buğra
dc.contributor.authorPektaş, Mehmet Bilgehan
dc.contributor.authorKocabaş, Aytaç
dc.contributor.authorSadi, Gökhan
dc.contributor.authorAkar, Fatma
dc.date.accessioned2021-05-05T22:14:15Z
dc.date.available2021-05-05T22:14:15Z
dc.date.issued2019
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.urihttps://doi.org/10.3390/medicina55050207
dc.identifier.urihttps://hdl.handle.net/20.500.12933/396
dc.descriptionKocabas, Aytac/0000-0001-7622-1932; SUMLU, Esra/0000-0002-5004-5958; Sadi, Gokhan/0000-0002-6422-1203en_US
dc.descriptionWOS:000472666200092en_US
dc.descriptionPubMed: 31137715en_US
dc.description.abstractBackground and Objectives: The excess consumption of fructose in the diet may cause metabolic syndrome, which is associated with an increased risk of kidney disease. There is limited data on probiotic treatment in high-fructose-induced metabolic syndrome. The present study aims to investigate whether the supplementation of Lactobacillus plantarum (L. plantarum) and Lactobacillus helveticus (L. helveticus) could provide an improving effect on the renal insulin signaling effectors, inflammatory parameters, and glucose transporters in fructose-fed rats. Materials and Methods: The model of metabolic syndrome in male Wistar rats was produced by fructose, which was given as 20% solution in drinking water for 15 weeks. L. plantarum and L. helveticus supplementations were given by gastric gavage from 10 to 15 weeks of age. Results: High-fructose consumption in rats reduced renal protein expressions of insulin receptor substrate (IRS)-1, protein kinase B (AKT), and endothelial nitric oxide synthase (eNOS), which were improved by L. plantarum and partially by L. helveticus supplementations. Dietary fructose-induced elevations in renal tissue levels of tumor necrosis factor (TNF-), interleukin (IL)-1, IL-6, and IL-10, as well as expression of IL-6 mRNA, were attenuated, especially in L. plantarum treated rats. The increased renal expression of sodium-glucose cotransporter-2 (SGLT2), but not that of glucose transporter type-5 (GLUT5), was suppressed by the treatment with L. plantarum. Conclusion: Suppression in insulin signaling pathway together with the induction of inflammatory markers and upregulation of SGLT2 in fructose-fed rats were improved by L. plantarum supplementation. These findings may offer a new approach to the management of renal dysregulation induced by dietary high-fructose.en_US
dc.description.sponsorshipGAZI UNIVERSITY RESEARCH FUNDGazi University [BAP 02/2017-04, FDK-2018-3392]en_US
dc.description.sponsorshipThis research was funded by the GAZI UNIVERSITY RESEARCH FUND, grant number BAP 02/2017-04 and the YILDIZ TECHNICAL UNIVERSITY RESEARCH FUND, grant number FDK-2018-3392.en_US
dc.language.isoengen_US
dc.publisherMdpien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdietary fructoseen_US
dc.subjectLactobacillus plantarumen_US
dc.subjectLactobacillus helveticusen_US
dc.subjectinsulin signalingen_US
dc.subjectinflammationen_US
dc.subjectglucose transportersen_US
dc.subjectkidneyen_US
dc.titleEffects of Lactobacillus Plantarum and Lactobacillus Helveticus on Renal Insulin Signaling, Inflammatory Markers, and Glucose Transporters in High-Fructose-Fed Ratsen_US
dc.typearticleen_US
dc.departmentAFSÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.contributor.institutionauthorKoca, Halit Buğra
dc.contributor.institutionauthorPektaş, Mehmet Bilgehan
dc.identifier.doi10.3390/medicina55050207
dc.identifier.volume55en_US
dc.identifier.issue5en_US
dc.relation.journalMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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