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dc.contributor.authorKendir, Gülsen
dc.contributor.authorSuntar, İpek
dc.contributor.authorÇeribaşı, Ali Osman
dc.contributor.authorKöroğlu, Ayşegül
dc.date.accessioned2021-05-05T22:14:15Z
dc.date.available2021-05-05T22:14:15Z
dc.date.issued2019
dc.identifier.issn0378-8741
dc.identifier.issn1872-7573
dc.identifier.urihttps://doi.org/10.1016/j.jep.2019.03.038
dc.identifier.urihttps://hdl.handle.net/20.500.12933/389
dc.descriptionSUNTAR, IPEK/0000-0003-4201-1325; Ceribasi, Ali Osman/0000-0002-6096-4042en_US
dc.descriptionWOS:000469152400015en_US
dc.descriptionPubMed: 30902746en_US
dc.description.abstractEthnopharmacological relevance: Ribes species are usually evergreen shrubs, represented by eight species in Turkey. Although they are known for their fruits with commercial importance, their leaves have been used as folk remedy in various areas in Turkey by rural population owing to their wound healing potential. Aim of the study: In the present study we aimed to assess the wound healing activity of the leaves of Ribes species growing in Turkey, namely, Ribes alpinum L., R. anatolica Behcet, R. petraeum Wulfen, R. multiflorum Kit. ex Romer & Schultes, R. nigrum L, R. orientale Desf., R. rubrum L, R. uva-crispa L. Materials and methods: Wounds were surgically induced on the dorsal parts of the rats and mice. Prepared herbal ointments were topically applied onto the wounds once daily. The effects of the extracts were evaluated by measuring the breaking strength and percentage of reduction in wounded area by comparing the results with the registered reference ointment, FITO Krem (R). Histopathological and antioxidant assays were also conducted. Since, R. nigrum was determined to be the most active species, we further investigated the wound healing potential of the subextracts of the methanol extract of R. nigrum leaves. Results: R. nigrum and R. multiflorum extracts significantly increased wound breaking strength. Significant reduction in the areas was determined for the wounded tissues treated with the ointments of R. nigrum and R. multiflorum extracts. Oxidative Stress Index was found to be lowest for R. orientale, R. nigrum and R. multiflorum. Among the subextracts of R. nigrum, ethyl acetate subextract was found to have promising effect. Conclusions: Methanol extracts of leaves of R. nigrum and R. multiflorum demonstrated significant wound healing effect. We can suggest that ethyl acetate subextract of R. nigrum may be a potential candidate to be used for the development of a wound healing agent.en_US
dc.description.sponsorshipScientific Research Projects Unit of Ankara University, Turkey [17H0237008]en_US
dc.description.sponsorshipThe present study was funded by Scientific Research Projects Unit of Ankara University, Turkey with the Project number of 17H0237008.en_US
dc.language.isoengen_US
dc.publisherElsevier Ireland Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExcisionen_US
dc.subjectBreaking strengthen_US
dc.subjectGrossulariaceaeen_US
dc.subjectIncisionen_US
dc.subjectRibes nigrumen_US
dc.subjectWound healingen_US
dc.titleActivity evaluation on Ribes species, traditionally used to speed up healing of wounds: With special focus on Ribes nigrumen_US
dc.typearticleen_US
dc.departmentAFSÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.contributor.institutionauthorKöroğlu, Ayşegül
dc.identifier.doi10.1016/j.jep.2019.03.038
dc.identifier.volume237en_US
dc.identifier.startpage141en_US
dc.identifier.endpage148en_US
dc.relation.journalJournal Of Ethnopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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