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dc.contributor.authorKorkmaz, Pınar
dc.contributor.authorDemirtürk, Neşe
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorTülek, Necla
dc.contributor.authorÖzgüler, Müge
dc.contributor.authorHarman, Rezan
dc.contributor.authorÇınar, Güle
dc.contributor.authorToka, Onur
dc.contributor.authorYörük, Gülşen
dc.contributor.authorAtaman Hatipoğlu, Çiğdem
dc.contributor.authorSarıgül, Figen
dc.contributor.authorSırmatel, Fatma
dc.contributor.authorİmre, Ayfer
dc.contributor.authorMıstanoğlu Özatağ, Duru
dc.contributor.authorKarakeçili, Faruk
dc.contributor.authorUral, Onur
dc.contributor.authorSümer, Şua
dc.contributor.authorAktuğ Demir, Nazlım
dc.contributor.authorKadanalı, Ayten
dc.contributor.authorÇomoğlu, Şenol
dc.contributor.authorÜçer, Şengül
dc.contributor.authorSaltoğlu, Neşe
dc.contributor.authorGünal, Özgür
dc.contributor.authorÖzkaya, Hacer Deniz
dc.contributor.authorYenilmez, Ercan
dc.contributor.authorÇetinkaya, Rıza Aytaç
dc.contributor.authorYüksel, Esma
dc.contributor.authorHakyemez, İsmail Necati
dc.contributor.authorMeriç Koç, Meliha
dc.contributor.authorTuncer Ertem, Günay
dc.contributor.authorBeştepe Dursun, Zehra
dc.contributor.authorÇelik, İlhami
dc.contributor.authorYılmaz, Emel
dc.contributor.authorEvik, Güliz
dc.contributor.authorKaya, Ali
dc.contributor.authorSüer, Kaya
dc.date.accessioned2021-05-05T22:14:13Z
dc.date.available2021-05-05T22:14:13Z
dc.date.issued2019
dc.identifier.issn1301-143X
dc.identifier.issn1309-1484
dc.identifier.urihttps://doi.org/10.5152/kd.2019.73
dc.identifier.urihttps://hdl.handle.net/20.500.12933/375
dc.descriptionCinar, Gule/0000-0002-7635-8848; Celik, Ilhami/0000-0002-2604-3776; Toka, Onur/0000-0002-4025-4537; Yoruk, Gulsen/0000-0002-0357-5884; Hakyemez, Ismail Necati/0000-0001-6133-9604; Tulek, Necla/0000-0002-3952-4982en_US
dc.descriptionWOS:000511173500009en_US
dc.description.abstractObjective: Both chronic hepatitis B (CHB) and hepatosteatosis may lead to necroinflammation in liver. Therefore, the presence of hepatosteatosis might negatively affect the efficacy of antiviral therapy. We aimed to determine the effect of hepatosteatosis on virological response in patients with CHB receiving entecavir (ETV) and tenofovir (TDF) treatment. Methods: The study was designed retrospectively. All patients receiving antiviral therapy due to CHB in the departments of Infectious Diseases and Clinical Microbiology of 29 different hospitals between January 2012 and June 2017 were searched by examining medical records. Results: A total of 1069 patients were included. Six hundred and fifty of the patients had been receiving TDF and 419 of them had been receiving ETV. The rate of virological response obtained at the 48'h week of TDF was higher in patients with steatosis (p=0.029). Virological response at the 24th week and 48th week of ETV were higher in the patients without steatosis (p=0.001). TDF and ETV therapies were compared in the patients with hepatosteatosis and it was found that the virological response at 48th week was higher in the TDF group. Conclusion: Although steatosis has an effect on virological response in the short-term results of nucleos(t)ide therapy, it does not have any effect on virological response in the long-term results.en_US
dc.language.isoturen_US
dc.publisherAvesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFatty liveren_US
dc.subjectentecaviren_US
dc.subjecttenofoviren_US
dc.titleHepatosteatozun Entekavir ve Tenofovir Tedavilerinde Virolojik Yanıta Etkisien_US
dc.title.alternativeEffect of Hepatosteatosis on the Virological Response in Entecavir and Tenofovir Therapies
dc.typearticleen_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorDemirtürk, Neşe
dc.identifier.doi10.5152/kd.2019.73
dc.identifier.volume32en_US
dc.identifier.issue3en_US
dc.identifier.startpage265en_US
dc.identifier.endpage274en_US
dc.relation.journalKlimik Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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