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dc.contributor.authorDemir, Ersin
dc.contributor.authorİnam, Onur
dc.contributor.authorSilah, Hülya
dc.contributor.authorKarimi-Maleh, Hassan
dc.date.accessioned2021-05-05T22:14:05Z
dc.date.available2021-05-05T22:14:05Z
dc.date.issued2020
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.urihttps://doi.org/10.1016/j.microc.2020.105531
dc.identifier.urihttps://hdl.handle.net/20.500.12933/268
dc.descriptioninam, onur/0000-0002-4726-1190; Demir, Ersin/0000-0001-9180-0609; Karimi-maleh, Hassan/0000-0002-1027-481Xen_US
dc.descriptionWOS:000598762700009en_US
dc.description.abstractBupivacaine, a local anesthetic that is often preferred in many wide ophthalmology applications, was investigated from different aspects such as electrochemical behavior, kinetic model, mechanism illumination, and analytical applications by cyclic voltammetry (CV) and square wave stripping voltammetry (SWSV) methods on glassy carbon electrode (GCE). Bupivacaine exhibited a well-defined anodic signal at nearly 850 mV, an irreversible and adsorption-controlled electrode process. Furthermore, a sensitive and selective SWSV method with a linear working range of 0.3-12.5 mg/L was developed for bupivacaine determination. Limits of detection (LOQ) and that of determination (LOD) were analyzed as 85 and 282 mu g/L, respectively. In addition, the most probable study mechanism was carried out for the first time by this study. The selectivity of some co-existences such as heavy metals, ketotifen, moxifloxacin, ciprofloxacin, cyclopentanate and tropicamide was studied in 1 mg/L bupivacaine determination. They did not have a serious effect on bupivacaine determination at 5% tolerance limits. Otherwise, bupivacaine was successfully analyzed in matrix samples without any pretreatment by the proposed SWSV. Consequently, a fast, reliable, inexpensive, portable, eco-friendly, and sensitive new method has been developed to analyze bupivacaine in real samples.en_US
dc.description.sponsorshipAfyonkarahisar University Health Sciences for their Scientific Research Projects (BAP) [19.ECZ.002]en_US
dc.description.sponsorshipWe would like to thank Afyonkarahisar University Health Sciences for their Scientific Research Projects (BAP) (Number: 19.ECZ.002), which provided financial opportunities for this study.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBupivacaineen_US
dc.subjectVoltammetryen_US
dc.subjectMechanism investigationen_US
dc.subjectKinetic modelingen_US
dc.titleStudies of mechanism, kinetic model and determination of bupivacaine and its application pharmaceutical formsen_US
dc.typearticleen_US
dc.departmentAFSÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.contributor.institutionauthorDemir, Ersin
dc.identifier.doi10.1016/j.microc.2020.105531
dc.identifier.volume159en_US
dc.relation.journalMicrochemical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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