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dc.contributor.authorSarıkürkçü, Cengiz
dc.contributor.authorSarıkürkçü, Rıfat Tayyib
dc.contributor.authorTepe, Bektaş
dc.date.accessioned2021-05-05T22:14:04Z
dc.date.available2021-05-05T22:14:04Z
dc.date.issued2021
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.urihttps://doi.org/10.1007/s11356-020-11695-y
dc.identifier.urihttps://hdl.handle.net/20.500.12933/251
dc.descriptionSarikurkcu, Cengiz/0000-0001-5094-2520en_US
dc.descriptionWOS:000607363600013en_US
dc.descriptionPubMed: 33411305en_US
dc.description.abstractIt is known that some Campanula species are traditionally used because of their anti-allergic, spasmolytic, antiphlogistic, antioxidant, and antiviral properties. This study was designed to evaluate the phytochemical composition, antioxidant, alpha-amylase, and tyrosinase inhibitory activity of ethyl acetate, methanol, and water extracts of Campanula macrostachya Waldst. & Kit. ex Willd. Chemical compositions were analyzed by spectrophotometric and chromatographic methods. Antioxidant activities of the samples were tested by using five different test systems. Enzyme inhibitory activities of the extracts were also studied. As a result of the LC-ESI-MS/MS analyses, chlorogenic acid, hesperidin, and hyperoside were found to be the major compounds of the extracts, especially the MeOH extract (6559.59, 2499.22, and 2047.66 mu g/g extract, respectively). Antioxidant activity tests have proven that MeOH extract showed higher activity than others (DPPH: 4.15 mg/mL, ABTS: 2.05 mg/mL, CUPRAC: 1.80 mg/mL, FRAP: 0.83 mg/mL, phosphomolybdenum: 1.69 mg/mL). Ferrous ion chelating activity of the water extract was 1.03 mg/mL. In alpha-amylase and tyrosinase inhibitory assays, EtOAc (IC50: 2.54 mg/mL) and MeOH (IC50: 1.51 mg/mL) extracts showed higher activity than the others did. In phosphomolybdenum, CUPRAC, FRAP, and tyrosinase inhibitory assays, the activity was strongly correlated with flavonoids, chlorogenic acid, hesperidin, and hyperoside. On the other hand, phenolic compounds have been found to contribute more to radical scavenging activity. Pearson correlation analysis showed that phenolics and flavonoids were not responsible for the alpha-amylase inhibitory activity of EtOAc extract.en_US
dc.language.isoengen_US
dc.publisherSpringer Heidelbergen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCampanula macrostachyaen_US
dc.subjectAntioxidant activityen_US
dc.subjectPhytochemistryen_US
dc.subjectalpha-Amylaseen_US
dc.subjectTyrosinaseen_US
dc.subjectChlorogenic aciden_US
dc.titleCampanula macrostachya: biological activity and identification of phenolics using a liquid chromatography electrospray ionization tandem mass spectrometry systemen_US
dc.typearticleen_US
dc.departmentAFSÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.contributor.institutionauthorSarıkürkçü, Cengiz
dc.identifier.doi10.1007/s11356-020-11695-y
dc.relation.journalEnvironmental Science And Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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