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dc.contributor.authorSarıkürkçü, Cengiz
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorTartaglia, Angela
dc.contributor.authorFerrone, Vincenzo
dc.contributor.authorJuszczak, Aleksandra M.
dc.contributor.authorÖzer, Mehmet Sabih
dc.contributor.authorTepe, Bektaş
dc.contributor.authorTomczyk, Michał
dc.descriptionPubMed: 32155959en_US
dc.description.abstractPhenolic compounds are secondary metabolites that are found ubiquitously in plants, fruits, and vegetables. Many studies have shown that regular consumption of these compounds could have a positive effect on our health. The aim of this study was to compare the phytochemical contents of the water extracts from three different plants used as folk remedies in Turkey: Aesculus hippocastanum, Olea europaea, and Hypericum perforatum. A liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS) analysis was performed to explore the phenolic profiles. The biological activities of these extracts were also evaluated in terms of their antioxidant activities (2,2-diphenyl-1-picrylhydrazyl DPPH, 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid ABTS, Ferric Reducing Antioxidant Power Assay FRAP, cupric ion reducing antioxidant capacity CUPRAC, ?-carotene, phosphomolybdenum, and metal chelating) and enzyme inhibitory properties (against acetylcholinesterase, butyrylcholinesterase, and tyrosinase). The aqueous extract of H. perforatum showed the highest levels of total phenolic, flavonoid, and saponin contents. Protocatechuic acid, vanillic acid, verbascoside, hesperidin, hyperoside, apigenin 7-hexosides, and quercetin were the most common compounds found in this species. The results confirm that A. hippocastanum, O. europaea, and H. perforatum represent a potential source of natural-derived molecules with positive properties that could be used as valid starting point for new food supplements, and drugs in the pharmaceutical, cosmetic, and food industries. © 2020 by the authors.en_US
dc.description.sponsorship2013?054 European Commission, ECen_US
dc.description.sponsorshipFunding: This research was funded by the Scientific Research Council of Celal Bayar University, Manisa?Turkey for financial support (Project Number: 2013?054). The funding body approved the design of the study, analysis, and interpretation of data, and publication of the manuscript.en_US
dc.description.sponsorshipAcknowledgments: The authors would also like to thank Dr. Olcay Ceylan for her kind help in identifying the plant material. Additionally, the work was written during doctoral studies (Ms Aleksandra M. Juszczak) under the project No. POWR.03.02.00?00?I051/16 co?funded from European Union funds, PO WER 2014?2020.en_US
dc.publisherMDPI AGen_US
dc.subjectAesculus hippocastanumen_US
dc.subjectBiological activitiesen_US
dc.subjectHypericum perforatumen_US
dc.subjectOlea europaeaen_US
dc.subjectPhytochemical analysisen_US
dc.titleEnzyme and biological activities of the water extracts from the plants aesculus hippocastanum, olea europaea and hypericum perforatum that are used as folk remedies in Turkeyen_US
dc.departmentAFSÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü
dc.contributor.institutionauthorSarıkürkçü, Cengiz
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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