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dc.contributor.authorDoğan, Mustafa
dc.contributor.authorAkdoğan, Müberra
dc.contributor.authorSabaner, Mehmet Cem
dc.contributor.authorGobeka, Hamidu Hamisi
dc.identifier.citationDogan, M., Akdogan, M., Sabaner, M. C., & Gobeka, H. H. (2022). Morphological changes in retinochoroidal microvasculature after caffeinated versus decaffeinated coffee consumption. Photodiagnosis and Photodynamic Therapy, 103138.en_US
dc.description.abstractBackground To investigate changes in retinochoroidal microvascular morphology after caffeinated versus decaffeinated coffee consumption in age- and gender-matched healthy individuals using optical coherence tomography (OCT) and OCT angiography (OCTA). Methods In this prospective, randomized clinical study, a staff member in charge of record keeping randomly assigned 48 healthy volunteers to two groups: caffeinated coffee consumers (24 eyes) and decaffeinated coffee consumers (24 eyes). Participants' ages and genders were recorded before consumption, and a comprehensive ophthalmologic exam was performed, followed by OCT and OCTA analyses before, 30 min, one, six, and 24 h after blindly consuming either of the coffees. Results Caffeinated and decaffeinated coffee consumers had mean ages of 23.45 ± 0.92 and 22.73 ± 1.13, respectively (p = 0.407). The following parameters changed significantly in caffeinated coffee consumers 30 min and 1 h post-consumption (pre-consumption versus 30 min versus one hour post-consumption; p < 0.05): a) parafoveal superficial capillary plexus vessel density (%): 54.45 versus 51.8 versus 51.92, b) parafoveal deep capillary plexus vessel density (%): 55.16 versus 52.45 versus 52.83, c) outer retinal flow area (%): 8.87 ± 1.91 versus 8.03 ± 1.88 versus 8.11 ± 1.93, d) choriocapillaris flow area (mm2): 20.95 ± 0.98 versus 19.82 ± 1.20 a versus 19.62 ± 0.95, and e) sub-foveal choroidal thickness (µm): 295.06 ± 5.45 versus 277.08 ± 5.33 versus 260.71 ± 58.61. No significant differences in any OCT and OCTA parameters were found between consecutive measurements in decaffeinated coffee consumers (p > 0.05). Conclusions Caffeinated coffee appears to transiently reduce parafoveal vessel density, capillary flow area, and sub-foveal choroidal thickness. Lack of these microvascular morphological changes in decaffeinated coffee suggests a potential caffeine-induced vasoconstrictive effect.en_US
dc.subjectCaffeinated coffeeen_US
dc.subjectCapillary flow areaen_US
dc.subjectDecaffeinated coffeeen_US
dc.subjectSpectral domain optic coherence tomographyen_US
dc.subjectOptic coherence tomography angiographyen_US
dc.subjectSub-foveal choroidal thicknessen_US
dc.subjectVessel densityen_US
dc.titleMorphological changes in retinochoroidal microvasculature after caffeinated versus decaffeinated coffee consumptionen_US
dc.departmentAFSÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorDoğan, Mustafa
dc.contributor.institutionauthorAkdoğan, Müberra
dc.contributor.institutionauthorSabaner, Mehmet Cem
dc.contributor.institutionauthorGobeka, Hamidu Hamisi
dc.relation.journalPhotodiagnosis and Photodynamic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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