dc.contributor.author | Doğan, Mustafa | |
dc.contributor.author | Akdoğan, Müberra | |
dc.contributor.author | Sabaner, Mehmet Cem | |
dc.contributor.author | Gobeka, Hamidu Hamisi | |
dc.date.accessioned | 2022-10-26T06:29:20Z | |
dc.date.available | 2022-10-26T06:29:20Z | |
dc.date.issued | 03.10.2022 | en_US |
dc.identifier.citation | Dogan, M., Akdogan, M., Sabaner, M. C., & Gobeka, H. H. (2022). Morphological changes in retinochoroidal microvasculature after caffeinated versus decaffeinated coffee consumption. Photodiagnosis and Photodynamic Therapy, 103138. | en_US |
dc.identifier.issn | 1873-1597 | |
dc.identifier.uri | https://doi.org/10.1016/j.pdpdt.2022.103138 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12933/1435 | |
dc.description.abstract | Background
To investigate changes in retinochoroidal microvascular morphology after caffeinated versus decaffeinated coffee consumption in age- and gender-matched healthy individuals using optical coherence tomography (OCT) and OCT angiography (OCTA).
Methods
In this prospective, randomized clinical study, a staff member in charge of record keeping randomly assigned 48 healthy volunteers to two groups: caffeinated coffee consumers (24 eyes) and decaffeinated coffee consumers (24 eyes). Participants' ages and genders were recorded before consumption, and a comprehensive ophthalmologic exam was performed, followed by OCT and OCTA analyses before, 30 min, one, six, and 24 h after blindly consuming either of the coffees.
Results
Caffeinated and decaffeinated coffee consumers had mean ages of 23.45 ± 0.92 and 22.73 ± 1.13, respectively (p = 0.407). The following parameters changed significantly in caffeinated coffee consumers 30 min and 1 h post-consumption (pre-consumption versus 30 min versus one hour post-consumption; p < 0.05): a) parafoveal superficial capillary plexus vessel density (%): 54.45 versus 51.8 versus 51.92, b) parafoveal deep capillary plexus vessel density (%): 55.16 versus 52.45 versus 52.83, c) outer retinal flow area (%): 8.87 ± 1.91 versus 8.03 ± 1.88 versus 8.11 ± 1.93, d) choriocapillaris flow area (mm2): 20.95 ± 0.98 versus 19.82 ± 1.20 a versus 19.62 ± 0.95, and e) sub-foveal choroidal thickness (µm): 295.06 ± 5.45 versus 277.08 ± 5.33 versus 260.71 ± 58.61. No significant differences in any OCT and OCTA parameters were found between consecutive measurements in decaffeinated coffee consumers (p > 0.05).
Conclusions
Caffeinated coffee appears to transiently reduce parafoveal vessel density, capillary flow area, and sub-foveal choroidal thickness. Lack of these microvascular morphological changes in decaffeinated coffee suggests a potential caffeine-induced vasoconstrictive effect. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.pdpdt.2022.103138 | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Caffeinated coffee | en_US |
dc.subject | Capillary flow area | en_US |
dc.subject | Decaffeinated coffee | en_US |
dc.subject | Spectral domain optic coherence tomography | en_US |
dc.subject | Optic coherence tomography angiography | en_US |
dc.subject | Sub-foveal choroidal thickness | en_US |
dc.subject | Vessel density | en_US |
dc.title | Morphological changes in retinochoroidal microvasculature after caffeinated versus decaffeinated coffee consumption | en_US |
dc.type | article | en_US |
dc.authorid | 0000-0001-7237-9847 | en_US |
dc.authorid | 0000-0003-4846-6312 | en_US |
dc.authorid | 0000-0002-0958-9961 | en_US |
dc.authorid | 0000-0002-7656-3155 | en_US |
dc.department | AFSÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı | en_US |
dc.contributor.institutionauthor | Doğan, Mustafa | |
dc.contributor.institutionauthor | Akdoğan, Müberra | |
dc.contributor.institutionauthor | Sabaner, Mehmet Cem | |
dc.contributor.institutionauthor | Gobeka, Hamidu Hamisi | |
dc.identifier.volume | 40 | en_US |
dc.identifier.startpage | 1 | en_US |
dc.identifier.endpage | 9 | en_US |
dc.relation.journal | Photodiagnosis and Photodynamic Therapy | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |